| P53在星形细胞瘤中的表达 |
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| 引用本文： | 李维平,蔡晓东,陈耕野,肖邦良,罗宏,张文燕. P53在星形细胞瘤中的表达[J]. 中国临床神经科学, 2000, 8(3): 187-188,194 |
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| 作者姓名： | 李维平 蔡晓东 陈耕野 肖邦良 罗宏 张文燕 |
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| 作者单位： | 1. 深圳市红十字会医院神经外科518035
2. 华西医科大学公共卫生学院610044 |
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| 摘 要： | 目的研究P53在星形细胞瘤中的表达与肿瘤病理分级的关系,讨论P53在星形细胞瘤预后判断上的价值.方法SP免疫组化法对110例星形细胞中P53的表达进行研究.结果在星形细胞瘤中,P53阳性表达率及其阳性细胞百分率均与病理分级无关.结论P53基因突变是星形细胞瘤发生发展过程的不同阶段中的一种相对独立的基因改变,P53蛋白的积聚在该肿瘤预后判断上的价值尚难肯定.深圳市科委课题资助
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| 关 键 词： | 星形细胞瘤 P53 免疫组化 |
| 修稿时间： | 2000-02-21 |
Expression of P53 in Astrocytomas |
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| LI Wei-Ping,CAI Xaio-Dong,CHEN Gen-Ye,XIAO Bong-Liang,LUO Huon,ZHANG Wen-Yan. Expression of P53 in Astrocytomas[J]. Chinese Journal of Clinical Neurosciences, 2000, 8(3): 187-188,194 |
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| Authors: | LI Wei-Ping CAI Xaio-Dong CHEN Gen-Ye XIAO Bong-Liang LUO Huon ZHANG Wen-Yan |
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| Abstract: | Aim:To examine the relationship between immuno-histochemical expression of P53 in astrocytoma and astrocy- toma with pathological grade, to discuss the value of P53 in astrocytoma prognosis estimation. Method: ASP immunohis- tochemical staining technique was undertaken for detecting the expression of P53 in 110 astrocytomas with 133 various patho- logical areas. Results: Theirpercents of P53-positive expression and of P53-positive expression cells were not correlated sig- nificantly with pathological grade in astrocytomas.Coclusion:The mutation of P53 gene was a relatively independent gene change in different stages of astrocytoma evolvement.The value of accumulation of P53 in astrocytoma prognosis extimation was not confirmed. |
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| Keywords: | P53 astrocytoma immunohistochemical |
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