Lineage and virulence of Streptococcus suis serotype 2 isolates from North America |
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Authors: | Fittipaldi Nahuel Xu Jiangu Lacouture Sonia Tharavichitkul Prasit Osaki Makoto Sekizaki Tsutomu Takamatsu Daisuke Gottschalk Marcelo |
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Affiliation: | Université de Montréal, St-Hyacinthe, Quebec, Canada. |
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Abstract: | We performed multilocus sequence typing of 64 North American Streptococcus suis serotype 2 porcine isolates. Strains were sequence type (ST) 28 (51%), ST25 (44%), and ST1 (5%). We identified nonrandom associations between STs and expression of the virulence markers suilysin (SLY), muramidase-relased protein (MRP), and extracellular factor (EF). Expression of pili encoded by the srtF and srtG pilus clusters was also nonrandomly associated with STs. ST1 strains were SLY+ EF+ MRP+ srtF pilus+ srtG pilus-. ST25 strains were SLY- EF- MRP- srtF pilus- srtG pilus+, and most ST28 strains were SLY- MRP+ EF- srtF pilus+ srtG pilus+. ST28 isolates proved essentially nonvirulent in a mouse infection model; ST25 strains showed moderate virulence and ST1 isolates were highly virulent. ST1 is responsible for a high proportion of S. suis disease in humans worldwide. Its presence in North America indicates that potential zoonotic S. suis outbreaks in this continent cannot be disregarded. |
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Keywords: | Streptococcus suis bacteria serotype 2 multilocus sequencing typing MLST North America zoonoses swine streptococci lineage virulence |
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