| 2D NMR Studies on the Benzodiheteropine and its Cycloaddition Products |
| |
| 引用本文： | 崔育新,刘晓峰,吴海涛,潘鑫复. 2D NMR Studies on the Benzodiheteropine and its Cycloaddition Products[J]. 中国药学, 1998, 0(4) |
| |
| 作者姓名： | 崔育新 刘晓峰 吴海涛 潘鑫复 |
| |
| 作者单位： | 北京医科大学药学院，兰州大学化学系 |
| |
| 摘 要： | 苯并硫氮杂卓是一类具有镇静作用的合成药物，对精神病，心脏病及高血压等疾病有一定疗效。为了深入探讨其结构与药效关系，应用１Ｈ１ＨＣＯＳＹ，１３Ｃ１ＨＣＯＳＹ和ＮＯＥＳＹ等２ＤＮＭＲ技术对苯并硫氮杂卓１及其环加成产物２～５进行了研究，对其１Ｈ、１３ＣＮＭＲ化学位移进行了指定，并分析讨论了化合物１～５的结构特征及苯并硫氮七元杂环呈船式构象的特点，各相关质子间的偶合常数也与讨论结果相符
|
| 关 键 词： | 苯并杂卓；二维核磁共振谱；构象；七元杂环 |
2D NMR Studies on the Benzodiheteropine and its Cycloaddition Products |
| |
| Yu Xin Cui ,Xiao Feng Liu ,Hai Tao Wu and Xin Fu Pan . National Research Laboratory of Natural and Biomimetic Drugs,School of Pharmaceutical Sciences,Beijing Medical University,Beijing. 2D NMR Studies on the Benzodiheteropine and its Cycloaddition Products[J]. Journal of Chinese Pharmaceutical Sciences, 1998, 0(4) |
| |
| Authors: | Yu Xin Cui Xiao Feng Liu Hai Tao Wu Xin Fu Pan . National Research Laboratory of Natural Biomimetic Drugs School of Pharmaceutical Sciences Beijing Medical University Beijing |
| |
| Affiliation: | Yu Xin Cui 1,Xiao Feng Liu 1,Hai Tao Wu 2 and Xin Fu Pan 2 1. National Research Laboratory of Natural and Biomimetic Drugs,School of Pharmaceutical Sciences,Beijing Medical University,Beijing 100083 2. Department of Chemistry,Lanzhou Uni |
| |
| Abstract: | |
| |
| Keywords: | Benzodiheteropine 2D NMR Conformation Seven membered heteroatomic ring |
| 本文献已被 CNKI 等数据库收录！ |
