Secondary Symptomatic Parvovirus B19 Infection in a Healthy Adult |
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Authors: | Julie Kaufmann Janet M Buccola Wendy Stead Christopher Rowley Michael Wong Carol K Bates |
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Institution: | (1) Division of General Medicine and Primary Care, Beth Israel Deaconess Medical Center, E/CC-6, 330 Brookline Avenue, Boston, MA 02215, USA;(2) Division of Infectious Diseases, Beth Israel Deaconess Medical Center, Boston, MA, USA |
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Abstract: | Parvovirus B19 is a common infection in adults and children. There are reports of secondary parvovirus infection in immunocompromised
persons, but no reports of symptomatic secondary infection in healthy persons. We describe a healthy 39-year-old woman who
presented with fever, rash, and arthralgia. Her symptoms were thought most compatible with parvovirus B19 infection, but she
reported prior positive parvovirus antibody 2 years earlier during prenatal care. Tests were therefore also sent for HIV,
streptococcal infection, hepatitis C, and Lyme disease. Testing revealed both elevated IgG and IgM antibodies for parvovirus
B19; previously, the patient was positive only for IgG. On a subsequent visit she related that a community outbreak of parvovirus
developed in her town and church group. We believe this case demonstrates that a symptomatic secondary infection with parvovirus
can occur in healthy persons, and that prior positive antibody test does not preclude the development of acute infection. |
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Keywords: | secondary parvovirus parvovirus recurrent parvovirus |
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