氯化壳聚糖季铵盐的调血脂活性研究

目的 观察氯化壳聚糖季铵盐(TMCC)对Wistar大鼠的调血脂作用。方法 大鼠随机分为正常(NG)组、高脂模型(HF)组、壳聚糖(CTS)组、TMCC组和考来烯胺(CLST)阳性对照组。除NG组给予普通饲料外,其余4组都给予高脂饲料。4周后,停止给予高脂饲料,NG、HF组给予生理盐水灌胃,其余3组,按166.7mg/(kg·d)分别给予CTS、TMCC、CLST。4周后测定各组血浆总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)。结果　与HF组比较,TMCC组能明显降低TC、TG、LDL-C水平(P<0.01),但对HDL-C作用不明显(P>0.05)。TMCC降低TC、LDL-C的能力比CTS和CLST强。结论CTS结构修饰物TMCC调血脂活性优于CTS。

Study on the blood lipid regulating of N-trimethyl chitosan chloride

Purpose To observe the blood lipid-regulating effects of N-trimethyl chitosan chloride in rats. Methods 50 rats were divided into five groups, which were the normal group, the high fat group, the GTS group, the TMCC group and the CLST group respectively .The normal group was given normal food, while the other four groups were given high fat food for 4 weeks. Then the CTS group, the TMCC group and the CLST group were treated with 166.7mg/(kg. d) . CTS, TMCC and CLST respectively by ig-administration, and the normal group, and the high fat group were given normal saline. Alter 4 weeks of treatment, blood lipids were tested. Results Compared with the high fat group, TMCC reduced TC, TG, LDL-C significantly(P<0.01), but had no effect on HDL-C(P>0.05) . In addition, the lowering TC and LDL-C capacity of TMCC was higher than that of CTS and CLST. Conclusion The blood lipid-regulating activities of TMCC (Modification of CTS) were higher than those of CTS.