| 小青龙汤药物血清对致敏大鼠腹腔肥大细胞脱颗粒以及组 … |
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| 引用本文： | 李仪奎,吴健宇.小青龙汤药物血清对致敏大鼠腹腔肥大细胞脱颗粒以及组 …[J].中国中西医结合杂志,2000,20(1):40-42. |
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| 作者姓名： | 李仪奎 吴健宇 |
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| 作者单位： | 上海中医药大学中药药理毒理研究中心!上海200032 |
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| 基金项目： | 国家自然科学基金!(No .39630 360 ) |
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| 摘 要： | 目的 研究小青龙汤抗过敏作用的机理。方法 分别形态法和荧光法观察了小青龙汤药物血清冻干粉对致敏大鼠腹腔肥大细胞（ＰＭＣ）脱颗粒和组织胺释放的影响。结果 给药１５ｍｉｎ、给药２ｈ后制备的药物血清冻干粉对ＰＭＣ脱颗粒和组织胺释放有明显的抑制作用，且二者的时效关系基本一致。结论 小青龙汤抗过敏作用与抑制ＰＭＣ释放过敏介质－组织胺有关。
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| 关 键 词： | 小青龙汤 血清冻干粉 腹腔肥大细胞 组织腔释放 |
Effect of Xiaoqinglong Decoction Drug Serum on Degranulation and Histamine Releasing of Peritoneal Mastocyte in Sensitized Rats |
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| Authors: | LI Yikui WU Jianyu WU Xiaofen Research Center of Pharmacology and Toxicology of Chinese Drugs Shanghai TCM University Shanghai |
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| Abstract: | Objective: To study the mechanism of anti allergic effect of Xiaoqinglong Decoction (XQLD). Methods: The influence of XQLD drug serum frozen powder on degranulation and histamine releasing of peritoneal mastocyte in sensitized rats was examined by morphologic and fluorimetric method. Results: The drug serum prepared by serum obtained 2 hours after medication for 15 min has obvious inhibitory effect on degranulation and histamine releasing of peritoneal mastocyte which showed a basically unified time effect relationship. Conclusion: The anti allergic effect of XQLD is related with the allergic medium (histamine) inhibition of releasing of peritoneal mastocyte. |
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| Keywords: | Xiaoqinglong Decoction serum frozen powader morphology fluorimetric method degranulation of peritoneal mastocyte histamine releasing |
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