| 吸烟与氡导致肺癌的氧化损伤与基因突变异同 |
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| 引用本文： | 刘海云,童建,李建祥. 吸烟与氡导致肺癌的氧化损伤与基因突变异同[J]. 环境与职业医学, 2009, 26(4): 405-408 |
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| 作者姓名： | 刘海云 童建 李建祥 |
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| 作者单位： | 苏州大学医学部放射与公共卫生学院卫生毒理学教研室; |
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| 摘 要： | 吸烟与氡是导致肺癌的两个主要因素，氧化损伤和基因突变是两个主要的机制。氧化损伤涉及多种自由基，而发生突变的基因主要包括p53基因、K-ras基因、p16基因、O^6-MGMT基因和FHIT基因。通过对吸烟和氡致肺癌的氧化损伤与基因突变方面的对比研究，可为肺癌发生的机制提供新的线索。
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| 关 键 词： | 吸烟 氡 肺癌 氧化损伤 基因突变 |
Differences in Oxidative Damage and Gene Mutation between Smoking and Radon-induced Lung Cancer |
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| LIU Hai-yun,TONG Jian,LI Jian-xiang. Differences in Oxidative Damage and Gene Mutation between Smoking and Radon-induced Lung Cancer[J]. Journal of Environmental & Occupational Medicine, 2009, 26(4): 405-408 |
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| Authors: | LIU Hai-yun TONG Jian LI Jian-xiang |
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| Affiliation: | Department of Health Toxicology;School of Radiology and Public Health;Medical College of Soochow University;Suzhou;Jiangsu 215123;China |
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| Abstract: | Smoking and radon are the two main factors that can induce lung cancer.Oxidative damage and gene mutation are concerned as two major carcinogenic mechanisms.Oxidative damage is associated with different free radicals and the mutational genes mainly include p53 gene,K-ras gene,p16 gene,O6-MGMT gene and FHIT gene.It will be possible to find new clues of the carcinogenic mechanisms by comparison study in oxidative damage and gene mutation induced by smoking and radon |
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| Keywords: | smoking radon lung cancer oxidative damage gene mutation |
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