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Peroxidation of lipids and degeneration of photoreceptors in the retina of rats with avitaminosis E
Authors:V. E. Kagan  G. V. Barybina  K. N. Novikov
Abstract:The formation of peroxidation products of lipids (hydroperoxides, dialkyl peroxides, ldquointermolecular cross linkagesrdquo) is sharply intensified in the retina of rats with alimentary avitaminosis Ein vivo and degeneration of the photoreceptors (mainly the layer of outer segments of the rods) develops. The experimental results are discussed on the basis of views regarding the antioxidant mechanism of action of agr-tocopherolin vivo.Laboratory of Physical chemistry of Biological Membranes, Departament of Biochemistry, Biological Faculty, M. V. Lomonosov Moscow State University. Institute of Chemical Physics, Academy of Sciences of the USSR, Moscow. (Presented by Academician of the Academy of Medical Sciences of the USSR S. E. Severin.) Translated from Byulleten' Éksperimental'noi Biologii i Meditsiny, Vol. 83, No. 4, pp. 411–413, April, 1977.
Keywords:rat retina  avitaminosis E  peroxidation of lipids  degeneration of photoreception layer of the retina
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