Abstract: | The formation of peroxidation products of lipids (hydroperoxides, dialkyl peroxides, intermolecular cross linkages) is sharply intensified in the retina of rats with alimentary avitaminosis Ein vivo and degeneration of the photoreceptors (mainly the layer of outer segments of the rods) develops. The experimental results are discussed on the basis of views regarding the antioxidant mechanism of action of -tocopherolin vivo.Laboratory of Physical chemistry of Biological Membranes, Departament of Biochemistry, Biological Faculty, M. V. Lomonosov Moscow State University. Institute of Chemical Physics, Academy of Sciences of the USSR, Moscow. (Presented by Academician of the Academy of Medical Sciences of the USSR S. E. Severin.) Translated from Byulleten' Éksperimental'noi Biologii i Meditsiny, Vol. 83, No. 4, pp. 411–413, April, 1977. |