硫酸镁和复方丹参联合对新生儿窒息心肌损伤治疗作用

目的:探讨硫酸镁和复方丹参联合应用对新生儿窒息(NA)心肌损伤的治疗作用及安全性。方法:NA合并心肌损伤患儿24例,随机分为对照组和治疗组各12例。对照组应用1,6-二磷酸果糖(FDP)治疗,剂量250mg.kg-1,静脉点滴连用7天。治疗组应用硫酸镁和复方丹参治疗:硫酸镁剂量200mg.kg-130 m in静脉滴注,继以10 mg.kg-1.h-1维持量用微量输液泵持续泵入,连用5天;复方丹参1 m l.kg-1静脉点滴,疗程7天。观察心肌钙蛋白I(cTnI)、肌酸激酶心肌同工酶(CK-MB)、肌酸激酶(CK)等指标的变化。结果:(1)治疗前治疗组和对照组cTnI分别为(1.83±2.01)ng.m l-1和(1.78±1.86)ng.m l-1;治疗后分别为(0.06±0.02)ng.m l-1和(0.15±0.11)ng.m l-1治疗后两组相比结果有显著性差异(P<0.05)。(2)治疗前治疗组和对照组CK-MB分别为(69.3±30.2)IU.L-1和(61.7±38.5)IU.L-1;治疗后两组分别为(31.3±12.5)IU.L-1和(43.2±16.8)IU.L-1,均较治疗前明显降低(P<0.05)。(3)治疗前治疗组和对照组CK分别为(968.3±580.2)IU.L-1和(897.5±502.7)IU.L-1;治疗后两组分别为(210.4±178.3)IU.L-1和(357.3±190.2)IU.L-1,与治疗前相比均有显著差异(P<0.05)。结论:硫酸镁和复方丹参对NA心肌损伤有明确治疗作用,无不良反应。

Comparative study on the therapeutic effects of magnesium suffate and salvia miltiorrhiza injection on neonatal asphyxia with myocardial injury

Objective:To investigate the therapeutic effect and safety of magnesium sulfate and salvia miltiorrhiza injection on neonatal asphyxia(NA) with myocardial injury.Methods:Twenty-four myocardial injury newborns were randomized into two groups,with 12 cases each.The control group was given Fructose-1, 6-diphosphate(FDP) 250mg·kg~(-1)intravenously for 7 days.The treatment group was given magnesium sulfate(200mg·kg~(-1)intravenously within 30 minutes),followed by maintenance infusion(10mg·kg~(-1)hourly) for 5 days and salvia miltiorrhiza injection(1ml·kg~(-1)) for 7 days.All the cases were finished basing on supportive and symptomatic therapy.The cardiac troponin I(cTnI),creatin kinase__MB(CKMB),creatin kinase(CK) were recorded before and after the treatment for comparison.Results:(1) The cTnI in the treatment and control groups before treatment was respectively 1.83±2.01 ng· m~(-1)and 1.78±1.86 ng· ml~(-1).There was significant difference between the treatment group(0.06±0.02ng·ml~(-1)) and the control group(0.15±0.11ng·ml~(-1)) after treatment.(P<0.05).(2) The CK-MB in the treatment and control groups before treatment was respectively 69.3±30.2IU·L~(-1)and 61.7±38.5 IU·L~(-1)(P>0.05),and respectively 31.3±12.5 IU·L~(-1)and 43.2±16.8 IU·L~(-1)(P>0.05) after treatment,both with marked decrease compared with those before treatment(P<0.05).(3) The CK in the treatment and control groups before treatment was respectively 968.3±580.2IU·L~(-1)and 897.5±502.7 IU·L~(-1)(P>0.05),and respectively 210.4±178.3 IU·L~(-1)and 357.3±190.2 IU·L~(-1)(P>0.05) after treatment.Both had marked difference before and after the treatment(P<0.05).Conclusion:The combined therapy of magnesium sulfate and salvia miltiorrhiza injection has definite therapeutic effect on myocardial injury in NA without any obvious adverse reaction.