| Abstract: | Peripheral blood lymphocytes of guinea pigs with experimental allergic encephalomyelitis (EAE) induced by a single injection of an oily suspension ofBordetellapertussis cells, when cultured with heterologous brain antigen undergo blast transformation, which is most marked on the 14th–21st day after sensitization. With the development of clinical symptoms of EAE the level of blast transformation of the lymphocytes fell and reached its minimum on the 40th day. It is postulated that this may be connected with the development of transient hypersensitivity and dissemination of sensitized lymphocytes into the CNS, leading to its injury.Laboratory of Allergy, I. I. Mechnikov Moscow Scientific-Research Institute of Vaccines and Sera, Ministry of Health of the USSR. (Presented by Academician of the Academy of Medical Sciences of the USSR, A. D. Ado.) Translated from Byulleten' Éksperimental'noi Biologii i Meditsiny, Vol. 78, No. 9, pp. 75–78, September, 1974. |
