Role of GABA(A) receptors in the ethanol-mediated inhibition of extracellular signal-regulated kinase |
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Authors: | Kalluri Haviryaji S G Ticku Maharaj K |
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Affiliation: | Department of Pharmacology, Mail Code 7764, The University of Texas Health Science Center, 7703 Floyd Curl Drive, San Antonio, TX 78229-3900, USA. |
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Abstract: | In the present study, we demonstrate the involvement of GABA(A) receptors in the ethanol-mediated modulation of extracellular signal-regulated kinases (ERK). Intraperitoneal (i.p.) administration of ethanol (3.5 g), flurazepam (75 mg) or (+)-5-methyl-10,11-dihydro-5H-dibenzo[a,d] cycloheptane-5,10-iminemaleate (MK-801) (0.4 mg/kg body weight) decreased, while picrotoxin (10 mg/kg body weight) increased, the phosphorylation of ERK following 10 min of their injection. However, the picrotoxin-induced phosphorylation of ERK was inhibited by ethanol, but was not affected by MK-801. These results indicate that ethanol's inhibitory effect on ERK phosphorylation may involve the modulation of GABA(A) receptor function. |
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Keywords: | Ethanol GABA (γ-amino butyric acid) MAP (mitogen-activated protein) kinase |
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