Dichapetalin-type triterpenoids and lignans from the aerial parts of Phyllanthus acutissima |
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| Authors: | Tuchinda Patoomratana Kornsakulkarn Jittra Pohmakotr Manat Kongsaeree Palangpon Prabpai Samran Yoosook Chalobon Kasisit Jitra Napaswad Chanita Sophasan Samaisukh Reutrakul Vichai |
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| Institution: | Department of Chemistry, Faculty of Science, Mahidol University, Rama VI Road, Bangkok 10400, Thailand. scptc@mahidol.ac.th |
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| Abstract: | Chemical investigation of the aerial parts of Phyllanthus acutissima resulted in the isolation of five new dichapetalin-type triterpenoids, acutissimatriterpenes A-E ( 1- 5), and two new lignans, acutissimalignans A ( 6) and B ( 7), along with two known lignans and three known ellagic acid derivatives. The structures of 1- 7 were determined mainly on the basis of spectroscopic methods. The compounds obtained were evaluated for cytotoxic and anti-HIV-1 activities. |
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