马来酸曲美布汀联合双歧杆菌治疗功能性肠胀气疗效观察

目的观察马来酸曲美布汀联合双歧杆菌对功能性肠胀气的疗效。方法将功能性肠胀气患者随机分为A、B两组，每组30例。A组服用马来酸曲美布汀联合双歧杆菌，B组仅服用双歧杆菌，疗程2周。结果治疗1周，A组症状积分明显下降（P〈0．01），B组无明显变化（P〉0．05）。治疗2周，A组症状积分下降更为明显（P〈0．01），B组较治疗前明显下降（P〈0．05），但高于A组（P〈0．05）。A组总有效率明显高于B组（1周有效率：腹胀：53．3％VS17．9％，伴随症状：58．3％VS28．6％；2周有效率：腹胀：76．7％VS42．9％，伴随症状：79．2％VS45．5％）。结论马来酸曲美布汀联合双歧杆菌对功能性肠胀气有较好疗效。

Efficacy of trimebutine maleate combined with bifidobacterium in treatment of patients wilh overful gas in intestinal tract

Objecctive To evaluate the efficacy of trimebufine mateate combined with bifidobactefittm in treatment of ovefful gas in intestinal tract of patients with alimentray dyskinesia.Methods By using a randomized and controlled clinical trial,the patients were divided into trimebutine maleate combined with bifidobacterium group（A group, n = 30）and bifidobacterium group（B group, n = 30） . The treaanent duration was 2 weeks.Results The symptom scores in A group decreased significanfly（ P 〈 0.01 ）after 1 week treatment and more remarkably（ P 〈 0.01）after 2 weeks treatment. In B group, tire symptom scores decreased significantly（ P 〈 0.05）only after 2 weeks treatment, and higher than A group（ P 〈 0.05）. Total efficacy rate of A group were higher than B group（ 1^st week efficacy rate： abdominal distension： 53.3% VS 17.9% .other symptoms： 58.3% VS 28.6% .2^nd week efficacy rate： abdomihal distension： 76.7% VS 42.9 %, other symptoms： 79.2 % VS 45.5 % ）. Conclusion Trimebutine maleate combined with bifidobactefium is effective in treatment of patients with overful gas in intestinal tract.