~(125)I粒子组织间植入对肺癌细胞A549的动物实验研究

目的提出^125I粒子组织间植入对肺癌细胞A549的有效剂量，确定^125I粒子组织间植入对缩小肺癌肿瘤的有效性。方法建立裸小鼠皮下肺癌移植瘤模型，分三组：对照组、空白组^125I粒子植入组。从粒子植入日起观察记录肿瘤大小变化，绘制肿瘤大小变化曲线。植入粒子后第28天处死动物，取瘤，测量最终体积大小及病理分析。结果肺癌细胞A549粒子植入组和对照组、空白组相比效果明显。结论证实了^125I粒子对缩小肺癌肿瘤的有效性。^粒子计量在0．8mCi对肺癌细胞A549肿瘤缩小的效果明显。

The animal experimental study on Iodine-125 Interstitial Brachytherapy in Pulmonary Carcinoma cell(A549)

Objective To study,Iodine-125 propose particles organizations A549 lung cancer cells implanted on the effective dose,identified Iodine-125 particles organizations narrow the implantation of the effectiveness of lung cancer.Methods The establishment of lung cancer in nude mice subcutaneous xenograft models,divided into three groups:the control group,the control group,Iodine-125 seed implantation group.From the date of implantation of particles observed changes in tumor size,tumor size drawing curves.Particles into the first 28 days after the animals were killed for tumor,measuring the ultimate size and pathological analysis.Results of lung cancer cells A549 seed implantation group and the control group,compared with blank evident result.Results Lung cancer cells A549 seed implantation group and the control group,compared with blank evident result.Conclusion Iodine-125 confirmed the particles to reduce the effectiveness of lung cancer.Iodine-125 particles measuring 0.8 mCi of lung cancer in the A549 tumor cells significantly reduced the effect.