肝硬变及肝癌癌旁肝组织中小多角肝细胞性质的免疫组化研究 |
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引用本文: | 张劲风,贺晓慧,刘彦仿,苏勤. 肝硬变及肝癌癌旁肝组织中小多角肝细胞性质的免疫组化研究[J]. 临床军医杂志, 1997, 0(1) |
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作者姓名: | 张劲风 贺晓慧 刘彦仿 苏勤 |
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作者单位: | 大连市解放军大连医学高等专科学校,西安市第四军医大学 |
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摘 要: | 应用免疫组织化学的方法对60例HCC、癌旁肝组织和47例肝硬变组织中HBxAg和IGF Ⅱ表达进行实验观察,以探讨小多角肝细胞(SPLC)的性质。结果显示,在癌旁肝和肝硬变的SPLC中HBxAg和IGF Ⅱ的阳性表达率分别为6914%和6667%,其中HBxAg阳性的SPLC中IGF Ⅱ阳性率为8214%,而HBxAg阴性的SPLC中IGF Ⅱ阳性率为3200%。IGF Ⅱ在HBxAg阳性的SPLC中的表达明显高于HBxAg阴性SPLC组(P<005)。结果表明,SPLC为癌旁肝和肝硬变等病变肝组织中一种幼稚的肝细胞成分,具有肝细胞和胆管细胞分化潜能,其增殖和分化的作用可能与肝细胞再生、胆管增生关系密切
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关 键 词: | 小多角肝细胞 肝硬变 胰岛素样生长因子 |
Characterizations of the Small Polygonal Liver Cell in Human Liver Cirrhosis and Tissues Surrounding Hepatocellular Carcinoma |
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Abstract: | In order to investigate the characterizations of the small polygonal liver cell (SPLC) in cirrhotic liver tissues and the liver tissues surrounding the tumors, 60 cases of hepatocellular carcinoma (HCC) and 47 cases of liver cirrhosis (LC) were examined with immunocytochemistry method using antibodies against IGF Ⅱ and HBxAg.The results showed that HBxAg and IGF Ⅱ positive rates were 69 14% and 66 67% respectively on SPLC in pericancerous liver tissues and LC, the positive rate of IGF Ⅱ were 82 14% in HBxAg positive SPLC group but 32 00% in HBxAg negative SPLC group.The expression of IGF Ⅱ in HBxAg positive SPLC was greater than that in HBxAg negative SPLC (χ 2 test, P <0 05).The above findings suggest that SPLC might be a kind of stem like cells and there were closely relations between proliferation and differentiation of SPLC and regeneration hepatocytes and biliary tuctular cells. |
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Keywords: | small polygonal liver cell liver cirrhosis insulin like growth factor |
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