Mechanisms of enhanced prevalence of asthma and atopy in developed countries |
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| Authors: | JM Hopkin |
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| Institution: | Lung Research Laboratory, Osler Chest Unit, Churchill Hospital, Oxford OX3 7LJ, UK |
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| Abstract: | Atopy — a T helper 2 cell driven hypersensitivity to innocuous antigens (allergens) which causes most cases of asthma — is of complex genetic and environmental origins. There is compelling epidemiological evidence for a rise in atopic disease in ‘westernised’ communities. The changing pattern of microbial exposure in early childhood is suggested to be the principal candidate mechanism for this rise. |
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| Keywords: | Abbreviations: FcεRI the high-affinity IgE receptor HAV hepatitis A virus IFN interferon IL interleukin Th T helper |
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