| 维生素D受体基因TaqⅠ和ApaⅠ位点单核苷酸多态性与特发性低枸橼酸尿症关系的研究 |
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| 引用本文： | 朱晨曦,叶章群,刘冠林,吴钉,邹义华,陈志强.维生素D受体基因TaqⅠ和ApaⅠ位点单核苷酸多态性与特发性低枸橼酸尿症关系的研究[J].临床泌尿外科杂志,2008,23(11):831-833. |
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| 作者姓名： | 朱晨曦 叶章群 刘冠林 吴钉 邹义华 陈志强 |
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| 作者单位： | 华中科技大学同济医学院附属同济医院泌尿外科,武汉,430030 |
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| 摘 要： | 目的：探讨维生素D受体（VDR）基因TaqⅠ和ApaⅠ位点单核苷酸多态性与特发性低枸橼酸尿症的关系及其临床意义。方法：实验筛选出无特发性低枸橼酸尿症者50名及特发性低枸橼酸尿症患者21名．通过PCR—RFLP技术检测VDR基因TaqⅠ及ApaⅠ位点单核苷酸多态性，并分析其与特发性低枸橼酸尿症之间的相关性。结果：两组间VDR基因ApaⅠ位点各基因型频率差异无统计学意义（P〉0．05）；而TaqⅠ各基因型频牢差异有统计学意义（P〈0．05）．在特发性低枸橼酸尿症患者组中TT型较为多见。且两组人群中基因型为TT者21h尿枸橼酸含量明显低于同组的其他基因型（P〈0．05）。结论1特发性低枸橼酸尿症与VDR—TaqⅠ单核降酸多态性间存在遗传相关性，而与VDR ApaⅠ单核苷酸多态性关系不明显。VDR基因TaqⅠ位点的TT型基因有望成为特发性低枸橼酸尿症的遗传标志基因。
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| 关 键 词： | 维生素D受体基因 单核苷酸多态性 特发性低枸橼酸尿症 |
Association between TaqI vitamin D receptor gene polymorphism and idiopathic hypocitraturia |
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| ZHU Chenxi,YE Zhangqun,LIU Guanlin,WU Ding,ZOU Yihua,CHEN Zhiqiang.Association between TaqI vitamin D receptor gene polymorphism and idiopathic hypocitraturia[J].Journal of Clinical Urology,2008,23(11):831-833. |
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| Authors: | ZHU Chenxi YE Zhangqun LIU Guanlin WU Ding ZOU Yihua CHEN Zhiqiang |
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| Institution: | 1Department of Urology;Tongji Hospital;Tongji Medical College;Huazhong University of Science and Technology;Wuhan;430030;China |
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| Abstract: | Objective:To investigate the relationship between TaqI vitamin D receptor(VDR)and ApaI vitamin D receptor polymorphism and idiopathic hypocitraturia repectively,and to evaluate it's clinical significance.Methods:75 volunteers were divided into 2 groups:50 volunteers with normal urine citrate(N);25 volunteers with idiopathic hypocitraturia(L).The polymorphisms of TaqI vitamin D receptor and ApaI vitamin D receptor were detected using PCR-RFLP technique and correlations were analyzed among these 2 groups each... |
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| Keywords: | Vitamin D receptor gene Polymorphism Idiopathic hypocitraturia |
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