| 促渗剂对祖师麻总香豆素体外经皮渗透的影响 |
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| 引用本文： | 于燕燕,狄留庆,黄 浩,毕肖林,祖 强,黄耀洲. 促渗剂对祖师麻总香豆素体外经皮渗透的影响[J]. 药学与临床研究, 2007, 15(1): 18-20 |
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| 作者姓名： | 于燕燕 狄留庆 黄 浩 毕肖林 祖 强 黄耀洲 |
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| 作者单位： | 南京中医药大学药学院,南京,210029;南京中医药大学药学院,南京,210029;南京中医药大学药学院,南京,210029;南京中医药大学药学院,南京,210029;南京中医药大学药学院,南京,210029;南京中医药大学药学院,南京,210029 |
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| 摘 要： | 目的:研究几种常用促渗剂对祖师麻总香豆素体外经皮渗透的影响.方法:采用Tp-5智能扩散仪,离体SD大鼠腹部皮肤为渗透屏障,以累计渗透量为指标,用HPLC法测定有效成分祖师麻甲素的浓度.结果:氮酮、冰片合用丙二醇可作为促渗剂,用于祖师麻总香豆素经皮吸收制剂,且氮酮合用丙二醇效果最好.结论:为研发祖师麻经皮给药制剂提供了实验依据.
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| 关 键 词： | 祖师麻总香豆素 祖师麻甲素 氮酮 1 2-丙二醇 油酸 冰片 肉豆蔻酸异丙酯 |
| 文章编号： | 1673-7806（2007）01-18-03 |
| 收稿时间： | 2006-11-30 |
| 修稿时间： | 2006-11-30 |
Influence of penetration enhancers on permeation of Daphne giraldii coumarins in vitro |
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| YU Yan-yan,DI Liu-qing,HUANG Hao,BI Xiao-lin,ZU Qiang and HUANG Yao-zhou. Influence of penetration enhancers on permeation of Daphne giraldii coumarins in vitro[J]. Pharmacertical and Clinical Research, 2007, 15(1): 18-20 |
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| Authors: | YU Yan-yan DI Liu-qing HUANG Hao BI Xiao-lin ZU Qiang HUANG Yao-zhou |
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| Affiliation: | School of Pharmacy, Nanjing University of Tradional Chinese Medicine, Nanjing 210029, China,School of Pharmacy, Nanjing University of Tradional Chinese Medicine, Nanjing 210029, China,School of Pharmacy, Nanjing University of Tradional Chinese Medicine, Nanjing 210029, China,School of Pharmacy, Nanjing University of Tradional Chinese Medicine, Nanjing 210029, China,School of Pharmacy, Nanjing University of Tradional Chinese Medicine, Nanjing 210029, China,School of Pharmacy, Nanjing University of Tradional Chinese Medicine, Nanjing 210029, China |
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| Abstract: | Objective: To study the effects of several penetration enhancers on Daphne giraldii Nitsche coumarins through skins in vitro. Methods: TP-5 automatic diffusion cell was adopted as the apparatus for in vitro skin permeation.Excised SD-rat abdomen skin was treated as penetration barrier.Using accumulative amount as index,the effective component daphnetin in the samples were measured by HPLC.Conclusion: Compared with blank skin,azone/propanediol,borneol/propanediol were found to be the proper penetration enhancers in the transdermal preparations of Zushima coumarins,and azone/propanediol were the best penetration enhancers to Zushima coumarins(P<0.01). |
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| Keywords: | Daphne giraldii Coumarins Daphnetin Azone Propanediol Olei acid Borneol Isopropyl myristate |
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