梯度掺锶羟基磷灰石仿生理条件下pH值稳定性与掺锶量

背景：锶掺入羟基磷灰石中不仅可以改善其降解性，而且还可以赋予羟基磷灰石材料一定的骨诱导性，但制备过程中由于使用酸性较强的稀磷酸为固化液，可能使掺锶羟基磷灰石的酸性增大。 目的：观察梯度掺锶羟基磷灰石仿生理条件下的pH值稳定性。 方法：配制标准的缓冲溶液，采用磷酸钙骨水泥水化方法制备摩尔分数为0%，1%，5%和10%掺锶羟基磷灰石梯度材料，每组取6个平行试样紫外线照射灭菌3 h备用。按照掺锶羟基磷灰石粉末质量:浸提递质=1g∶10 mL比例配制浸提掖，置于孵箱中，不同时间点测量梯度材料的pH值。 结果与结论：不同时间点测量在培养液中浸泡的材料pH值均稳定呈现弱碱性。提示，掺锶羟基磷灰石的pH值稳定呈现弱碱性，有利于成骨和内环境的稳定。

The pH value stability and strontium quantity of gradient strontium-incorporated hydroxyapatite under biomimic conditions

BACKGROUND: The strontium-doped hydroxyapatite can not only improve its degradation property, but also provide osteoinduction for hydroxyapatite materials, but strong acid phosphoric acid serves as the curing fluid in the preparation process, thus increase the acidity of strontium-doped hydroxyapatite. OBJECTIVE: To study the pH value of gradient strontium-incorporated hydroxyapatite powders in biomimic situation. METHODS: Standard buffer solution was prepared. Gradient strontium-incorporated hydroxyapatite powders with 0%, 1%, 5% and 10% strontium were fabricated using calcium phosphate bone cement through a hydration process. There were 6 parallel samples in each group, underwent ultraviolet radiation sterilization 3 hours. The leaching liquid was prepared at a ratio of strontium-incorporated hydroxyapatite powders: permeable medium = 1 g : 10 mL, placed in the incubator. The pH values of the gradient materials were measured at different time points. RESULTS AND CONCLUSION: In the tests of pH value, all materials shown alkalescence. The gradient strontium-incorporated hydroxyapatite powders show a stable alkalescence in biomimic situation, they are beneficial for osteogenesis and internal environment stability.