羟丙基甲基纤维素对房角组织影响的实验研究

为了探讨羟丙基甲基纤维素(HPMC)进入前房后对房角组织的影响,将24只纯白家兔随机分成2组实验组40眼,前房注射2%HPMC,对照组8眼,其中一眼做正常对照,7眼前房注射BSS,实验组又按眼压正常和增高分为A,B两组.分别于注射后第5d、3周、10周采集标本行病理检查.发现注射初期,实验A组可见到小梁网轻度扩张,房水丛管腔内壁内皮细胞胞质内空泡增多,实验B组可见小梁间隙增宽,胶原纤维及细胞间质纤维增生,房水丛管壁内皮细胞空泡明显增多,但追踪观察远期皆恢复正常.实验表明HPMC进入前房并存留可导致一过性眼压增高并可由此引起房角组织发生病理改变,但为可逆性变化.HPMC本身对房角组织无毒性和破坏性.

An Experimental Study on the Effect of Hydroxypropyl Methylcellulose on Anterior Chamber

The effect of hydroxyprolpyl methylcelulose (HPMC) injected into anterior chamber on filtering angle tissues was studied Twenty four rabbits were randomly divided into two groups: the experimental group included 40 eyes receiving HPMC which was injected into anterior chamber and the control group included 8 eyes (one served as normal control and the remaining were injected with balanced salt solution) According to the intaocular pressure (IOP) was normal or elevated ,the experimental group was further divided into group A and B The tissul specimen of filtering angle were collected to perform pathological examination at 5 days, 3 weeks ,and 10 weeks after injection During the early period, in groupA,the trabecular meshwork dilated slightly, the vacuoles increased in endothelial cells of inner wall of Schlemm's canal In group B, the space of trabeculum broadened, there were accumulation of collagen and intercellular fibrosis, the vacuoles significantly increased in endothelial cells of inner wall of Schlemm's canal But the change mentioned above all recovered to normal appearance on the later stage of long term following observationHPMC injected into anterior chamber may cause temporary elevation of IOP and pathological change of filtering angle, but the change was reversible HPMC is not toxic or destructive to the tissues of anterior chamb angle