Stability of a transdermal salmon calcitonin formulation |
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| Authors: | Chang Shu-Lun Hofmann Günter A Zhang Lei Deftos Leonard J Banga Ajay K |
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| Affiliation: | a Department of Pharmacal Sciences, School of Pharmacy, Auburn University, Auburn, Alabama, USA.b Genetronics, Inc., San Diego, California, USA.c UCSD and the San Diego VA Medical Center, La Jolla, California, USA.d Department of Pharmaceutical Sciences, School of Pharmacy, Mercer University, Atlanta, Georgia, USA. |
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| Abstract: | This study was designed to monitor the stability of salmon calcitonin during storage conditions, under the electric fields generated during iontophoresis and electroporation, in contact with transdermal glass diffusion cells, and during transport through skin. The formulation in a citrate buffer (pH 4.0) was stable in storage for short-term studies but degraded significantly on extended storage. Albumin was able to minimize adsorption in contact with glass surfaces, and aprotinin was able to minimize proteolytic degradation in contact with skin. The formulation was stable under electric field, but there was a loss due to adsorption if salt bridges were used. |
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| Keywords: | Electroporation Formulation Iontophoresis Stability Transdermal Delivery |
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