| 血浆内皮素在颅脑外伤中的变化和病理意义 |
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| 引用本文： | 姜德华,李香俊,王延国,玄汉石.血浆内皮素在颅脑外伤中的变化和病理意义[J].中国组织工程研究与临床康复,1999,3(3):332-333. |
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| 作者姓名： | 姜德华 李香俊 王延国 玄汉石 |
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| 作者单位： | 1. 南京铁道医学院附属徐州医院,徐州,221009
2. 延边大学医学院 |
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| 摘 要： | 目的：探讨内皮素在颅脑损伤中的作用。方法：观察了１５例重型和１６例轻中型颅脑损伤病人２４ｈ内、１周及２周血浆内皮素含量的变化。结果：颅脑损伤２４ｈ内两组病人血浆内皮素均明显升高，且重型组明显高于轻中型组（Ｐ＜０．０１），伤后１周下降，但重型组仍明显高于正常对照组（Ｐ＜０．０５），伤后２周基本恢复正常。结论：分析了内皮素升高的原因和病理意义，提示临床上可将血浆内皮素做为判断伤情轻重的一项生化参考指标。
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| 关 键 词： | 颅脑损伤 内皮素 |
| 修稿时间： | 1998年6月30日 |
Changes of Plasma Endothelim Level and its Pathophysiologic Significance in Brain Injury |
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| Jiang DeHua,Xu zhou Hospital affiliated to Nan jing Rail Medical College,Xu zhou ,L XiangJun,Wang YanGuo.Xuan Hanshi.Changes of Plasma Endothelim Level and its Pathophysiologic Significance in Brain Injury[J].Journal of Clinical Rehabilitative Tissue Engineering Research,1999,3(3):332-333. |
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| Authors: | Jiang DeHua Xu zhou Hospital affiliated to Nan jing Rail Medical College Xu zhou L XiangJun Wang YanGuoXuan Hanshi |
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| Institution: | Jiang DeHua,Xu zhou Hospital affiliated to Nan jing Rail Medical College,Xu zhou 221009,L XiangJun,Wang YanGuo.Xuan Hanshi. Affiliated Hospital of Yanbian University College of Medicine |
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| Abstract: | Objective:To explore the effect of endothelim(ET) on brain injury.Methods:We observed the changes of plasma ET of 15 cases of heavy brain injury and 16 cases of low-middle brain injury at 24 hours,in one week and two weeks.Results:The results showed that ET level increased at 24 hours in injury groups and ET contents of heavy injury group significantly were higher than that of low-middle injury group(P<0.01).ET level decreased after one week in injure groups,but ET contents of severe injury group were still higher than that of control group(P<0.05).After two weeks,ET level return to normal in injury groups.Conclusion:We analysed the factor of changes of ET and its pathophysiologic significance.The results suggested that ET may be a useful clinical biochemical indicator for judging brain injury degree. |
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| Keywords: | Brain Injury Endothelim |
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