Exploration of 16 candidate genes identifies the association of IDE with Alzheimer's disease in Han Chinese |
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Authors: | Wang Fen Shu Chang Jia Longfei Zuo Xiumei Zhang Yongbiao Zhou Aihong Qin Wei Song Haiqing Wei Cuibai Zhang Feng Hong Zhen Tang Muni Wang Duen-Mei Jia Jianping |
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Institution: | Department of Neurology, Xuan Wu Hospital of the Capital Medical University, Beijing, China. |
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Abstract: | Alzheimer's disease (AD) has a complex pattern of inheritance and many genes have recently been reported to contribute to the disease susceptibility. We selected 106 SNPs within 16 candidate genes and performed a multistage association study using 4 sample sets consisting of 731 AD patients and 738 control subjects to identify genetic factors for AD in Han Chinese. A single nucleotide polymorphism (SNP) in the insulin degrading enzyme gene (IDE), rs3781239, showed a significant association with AD. The C allele increased the risk of AD 1.72-fold than the G allele (odds ratio OR] = 1.72, 95% confidence interval CI] = 1.17-2.53, p = 0.006) and CC carriers had a 4.89-fold higher risk for AD than that of the carriers with CG and GG genotypes (odds ratio = 4.89, 95% CI = 1.85-12.91, p = 0.001). Moreover, the CC genotype was significantly associated with earlier age at onset (p = 0.001, hazard ratio HR] = 2.09, 95% CI = 1.38-3.18). Our data suggest that the polymorphism of IDE is associated with susceptibility to Alzheimer's disease in Han Chinese. |
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Keywords: | Insulin degrading enzyme Alzheimer's disease Genetics Single nucleotide polymorphism Association |
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