高敏C反应蛋白在急性冠状动脉综合征中临床意义的研究

目的探讨高敏C反应蛋白(hsCRP)与急性冠状动脉综合征(ACS)病变程度的关系及临床意义。方法测定经冠状动脉造影证实为ACS患者(n=54)的血清hsCRP浓度,与正常对照组(n=18)的hsCRP浓度相比较,分析二组间及ACS组中,冠状动脉病变支数与相应hsCRP浓度的关系。结果hsCRP浓度在对照组,不稳定型心绞痛组,急性心肌梗死组依次增高,分别为(1.474±1.063)mg/L,(5.753±4.168)mg/L,(12.140±6.679)mg/L。在ACS组中,单支病变组,双支病变组,三支病变组,其hsCRP浓度也依次增高,分别为(5.513±2.458)mg/L,(8.321±4.785)mg/L,(12.423±4.104)mg/L。结论hsCRP可作为ACS患者判断病情严重程度及预后的指标。

Clinical value of high sensitivity C-reactive protein in patients with acute coronary syndrome

Objective To explore the relationship between high sensitivity C-reactive protein (hsCRP) and the severity of acute coronary syndrome (ACS). Methods The serum hsCRP levels were tested in 72 cases who underwent coronary angiography (CAG), ACS was present in 54 and absent in 18 cases as normal control group, the results of the two groups and different numbers of diseased coronary vessels in ACS group were analyzed. Results the serum hsCRP levels were (1.474)±1.063 mg/L, 5.753±4.168 mg/L, 12.140 ±6.679 mg/L,respectively,for the normal control gronp ,the unstable angina pectoris group and acute myocardial infarction group.hsCRP levels in the ACS groups were significantly higher than that in normal control group .In the ACS group, the serum hs CRP levels were 5.513±2.458 mg/L, 8.321±4.785 mg/L, 12.423±4.104 mg/L, respectively, for the 1-vessel-disease group, the 2-vessel-disease group and 3-vessel-disease group. The hsCRP levels of the three groups were significantly higher than that of the normal control group. Conclusion the hsCRP level was closely associated with ACS as a indication and predictor for the severity and prognosis of coronary heart disease.