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毓宫合剂对双卵巢切除后大鼠作用的实验研究
引用本文:杨鉴冰,崔晓萍,王宗柱,张彩晴. 毓宫合剂对双卵巢切除后大鼠作用的实验研究[J]. 山西中医学院学报, 2002, 3(1): 18-20
作者姓名:杨鉴冰  崔晓萍  王宗柱  张彩晴
作者单位:1. 陕西中医学院,陕西,咸阳,712083
2. 解放军323医院,陕西,西安,710054
基金项目:陕西省教育厅专项科研基金资助项目(No.01JK103)
摘    要:目的:观察复方中药毓宫合剂对卵巢切除术后大鼠血清E2含量、子宫重量、组织结构的影响,并探讨其治疗机理。方法:切除大鼠双侧卵巢,分组给以生理盐水、乙烯雌酚、毓宫合剂4周,然后测定血清E2含量、称取子宫湿重、观察子宫组织结构。结果:生理盐水组血清E2含量明显低于其它各组(P<0.01),毓宫合剂组与乙烯雌酚组间无差异;毓宫合剂组大鼠子宫重量增加(P<0.01),子宫平滑肌细胞增生肥大,子宫及子宫内膜发育。结论:毓宫合剂能够升高去卵巢大鼠血清E2含量,促进子宫及子宫内膜发育。

关 键 词:毓宫合剂  去卵巢大鼠模型  子宫发育
文章编号:1671-0258(2002)01-0018-03
修稿时间:2002-01-26

Experimental Study of Yugong Mixture on Bilateral Ovariectomy Rats
Yang Jianbing et al.. Experimental Study of Yugong Mixture on Bilateral Ovariectomy Rats[J]. Journal of Shanxi College of Traditional Chinese Medicine, 2002, 3(1): 18-20
Authors:Yang Jianbing et al.
Abstract:Objective:To observe the Yugong mixture' s effects on serum E 2 ,uterine weight and structure of bilateral ovariectorny rats,then to probe its mechanism.Methods:After the rats were spayed and grouped,the normal sali ne,Yugong m ixture and diethylstilbestrol were given to the rats respectively. Final-ly determine the content of E 2 ,uterine weight ,observe the tissue structure.Results:The serum E 2 of saline group was obviously lower than that of any other groups(P<0.0 1),while there was no significant dif-ference between Yugong mixture grou p and diehystilbestrol group.The we ight of uterus increased(P<0.01),cell s of uterine smooth muscle multiplied and enlarged,the uterus and e ndometrium developed in the Yugong mixture group.Conclusions:Yugong Mixture can increase the seru m E 2 in the spayed rats and improve the development of the uteru s and endometriu m of the spayed rats.
Keywords:Yugong mixture  Spayed rat model  Ut erine development  
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