Characterization of full-length VP4 genes of OP354-like P[8] human rotavirus strains detected in Bangladesh representing a novel P[8] subtype |
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| Authors: | Shigeo Nagashima Nobumichi Kobayashi Shyamal Kumar Paul Mohammed Mahbub Alam Mamta Chawla-Sarkar and Triveni Krishnan |
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| Institution: | (1) Department of Hygiene, Sapporo Medical University School of Medicine, S-1 W-17 Chuo-ku, Sapporo Hokkaido, 060-8556, Japan;(2) Department of Microbiology, Mymensingh Medical College, Mymensingh, Bangladesh;(3) Faculty of Veterinary Science, Bangladesh Agricultural University, Mymensingh, Bangladesh;(4) Division of Virology, National Institute of Cholera and Enteric Diseases, Kolkata, India |
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| Abstract: | The G1 and G9 rotavirus strains MMC71 and MMC38 (subgroup II, NSP4 genogroup B), respectively, isolated from children in Bangladesh,
were analyzed genetically. Full-length VP4 genes of these strains had 98.9% identity to each other and showed 83.9–89.4% identity
to those of the P4] and P8] rotaviruses. Phylogenetic analysis of VP4 nucleotide sequences revealed that strains MMC38 and
MMC71 were located in a lineage of P8] strains. However, the cluster was highly divergent from the previously established
P8] strains. The VP8* portions of strains MMC38 and MMC71 showed more than 93.9% nucleotide sequence identity to OP354-like
P8] strains, and these strains were clustered into the same lineage. These findings indicate that the VP4 of these strains
should be classified into a subtype of the P8] genotype (P8]b) that is distinct from that of common P8] rotaviruses (P8]a). |
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