A 型肉毒毒素治疗半面痉挛及眼睑痉挛

目的观察Ａ型肉毒毒素治疗半面痉挛及眼睑痉挛的效果。方法Ａ型肉毒毒素局部注射（每点２．５～５Ｕ）治疗眼睑痉挛１２例（１５侧）及半面痉挛３８例。结果完全缓解分别为１０例（１３侧，占８６．７％）及３２例（８４．２％），明显缓解分别为２例（１３．３％）及５例（１３．２％），部分缓解分别为０例及１例（２．６％）。总有效率１００％。药效作用时间分别为１０～２４周（平均１８周）及１４～３２周（平均２２周）。局部副反应轻微、短暂，包括轻度面瘫８例、眼睑下垂４例、流泪４例，无全身反应及过敏反应。结论Ａ型肉毒毒素局部注射是治疗眼睑痉挛及半面痉挛的一种安全、有效、简便方法。

Blepharospasm and hemifacial spasm treated with botulinum A toxin injection

Objective To study the efficacy of botulinum A toxin (BTA) injections for the treatment of blepharospasm and hemifacial spasm (HFS). Methods Twelve patients with blepharospasm and thirty eight patients with HFS were treated with BTA local injections (2.5U to 5U for each injection). Results Of the fifty patients, ten (86.7%) in blepharospasm and thirty two (84.2%) in HFS were completely relieved, two (13.3%) and five (13.2%) were remarkably relieved respectively, zero and one (2.6%) were partial relieved respectively. All patients experienced relief from spasm. The duration of the effect in blepharospasm were 10 to 24 weeks (mean, 18 weeks) and in HFS 14 to 32 weeks (mean, 22 weeks). The local side effects were transient and mild, including minor facial paralysis in eight patients, ptosis in four patients and tearing in four patients. No systemic adverse and allergic reactions were noted. Conclusion Botulinum A toxin local injection is a safe, effective and simple means for the treatment of blepharospasm and HFS.