| 福辛普利联合氨氯地平治疗原发性高血压 |
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| 引用本文： | 龚向芳,张熙洁.福辛普利联合氨氯地平治疗原发性高血压[J].职业与健康,2008,24(23):2614-2615. |
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| 作者姓名： | 龚向芳 张熙洁 |
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| 作者单位： | 河北省唐山市工人医院,063000 |
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| 摘 要： | 目的观察福辛普利联合氨氯地平治疗原发性重度高血压的作用及对肝肾功能的影响。方法100例原发性重度高血压的患者随机分2组，观察组口服福辛普利和氨氯地平，对照组口服氨氯地平，治疗12个月，随访时间为1a，以24h动态血压、血清天冬氨酸转氨酶、丙氨酸转氨酶、谷氨酰转肽酶、尿素氮、肌酐，24h尿蛋白定量检查结果，进行2组的对比。结果2组患者治疗后血压均有显著下降（P〈0．01），观察组下降的幅度明显高于对照组（P〈0．05）。观察组24h尿蛋白定量无显著变化（P〉0．05），治疗组24h尿蛋白定量明显下降（P〈0．05）。2组天冬氨酸转氨酶，丙氨酸转氨酶，γ-谷氨酰转肽酶，尿素氮，肌酐治疗前后无显著变化（P〉0．05）。结论福辛普利联合氨氯地平降压效果优于单药应用氨氯地平，不增加肝。肾功能损伤程度，并可减少尿蛋白。
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| 关 键 词： | 福辛普利 氨氯地平 原发性高血压 肝功能 肾功能 |
Fosinopril and Amiodipine on Treatment of Primary Hypertension |
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| GONG Xiang-fang,ZHANG Xi-jie.Fosinopril and Amiodipine on Treatment of Primary Hypertension[J].Occupation and Health,2008,24(23):2614-2615. |
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| Authors: | GONG Xiang-fang ZHANG Xi-jie |
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| Institution: | Tangshan Worker's Hospital;Hebei;063000;China |
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| Abstract: | Objective] To observe the effect of Fosinopril and Amlodipine on treatment of Hypertension and the influence to liver and renal function.Methods] 100 patients with primary hypertension were randomly divided into2 groups,observation group received combination of Fosinopril and Amlodipine orally,and control group received Amlodipine orally,for 12-month treatment,follow-up duration for 1 year.The 24-hour ambulatory blood pressure,serum GOT,GPT,GPT,BUN,Cr and 24HUPQ were observed and the results were compared... |
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| Keywords: | Fosinopril Amlodipine Primary hypertension Liver function Renal function |
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