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| 白血病端粒酶活动度与三氧化二砷治疗观察 | |
| 引用本文： | 王韫芳,郑晓飞,李昕权. 白血病端粒酶活动度与三氧化二砷治疗观察[J]. 现代肿瘤医学, 2005, 13(3): 327-328 |
| 作者姓名： | 王韫芳 郑晓飞 李昕权 |
| 作者单位： | 1. 北京输血医学研究所,北京,100039 2. 北京放射医学研究所,北京,100039 3. 武警总医院血液科,北京,100039 |
| 摘 要： | 目的观察白血病端粒酶活性与三氧化二砷的治疗效果。方法端粒重复扩增法结合光密度测定和临床治疗观察。结果急性白血病均表现出较高的端粒酶活性，用三氧化二砷治疗后，获得临床血液学缓解及端粒酶活性降低，并在维持缓解间保持较低水平。结论观察端粒酶活动度有助于l临床判断病情转归及三氧化二砷的治疗反应。 |
| 关 键 词： | 白血病 端粒酶 三氧化二砷 |
| 文章编号： | 1672-4992(2005)03-327-02 |
| 修稿时间： | 2004-11-08 |
Observation on activity of telomorase and treatment of arsenic trioxide in leukemia |
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| WANG Yun-fang,ZHENG Xiao-fei,Li Xin-quan. Observation on activity of telomorase and treatment of arsenic trioxide in leukemia[J]. Journal of Modern Oncology, 2005, 13(3): 327-328 | |
| Authors: | WANG Yun-fang ZHENG Xiao-fei Li Xin-quan |
| Affiliation: | WANG Yun-fang~1,ZHENG Xiao-fei~2,Li Xin-quan~3. ~1Beijing Institute of Transfusion of Hematology,Beijing 100850 China, ~2Beijing Institute of Radiology Medicine,Beijing 100850 China, ~3Department of Hematology,General Hospital of Chinese Armed Police Force,Beijing 100039 China. |
| Abstract: | Objective To evaluate telomerase activity and effect of arsenic trioxide on acute leukemia. Methods The telomeric repeat amplification protocol (TRAP)combined with semiquantitative analysis and clinical obsevation of arsenic trioxide treatment in leukemic patients. Results The strong telomerase activity was observed in leukemia patients. The clinical hematological remission were achieved and telomerase activity was decreased following arsenic trioxide treatment in acute leukemia. Conclusion The telomerase activity is related to clinical effect of arsenic trioxide treatment in leukemia. |
| Keywords: | leukemia telomerase arsenic trioxide |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |