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Electric stimulation on human cortex suppresses fast cortical activity and epileptic spikes |
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| Authors: | Kinoshita Masako Ikeda Akio Matsumoto Riki Begum Tahamina Usui Keiko Yamamoto Junichi Matsuhashi Masao Takayama Motohiro Mikuni Nobuhiro Takahashi Jun Miyamoto Susumu Shibasaki Hiroshi |
| Institution: | Departments of Neurology;and Neurosurgery;, and Human Brain Research Center, Graduate School of Medicine, Kyoto University, Kyoto, Japan |
| Abstract: | Summary: Purpose: To investigate underlying mechanisms and adequate parameters for electric cortical stimulation to inhibit epileptic focus in humans. Methods: A patient with intractable partial epilepsy had subdural electrodes implanted for preoperative evaluation. Cortical functional mapping was performed by using 50-Hz alternating square pulse of 0.3-ms duration, 1 to 7 mA, within 5 s. Spike frequency and electrocorticogram (ECoG) power spectra were compared before and after the stimulation when epileptic focus and distant area were stimulated. A similar comparison also was performed in low-frequency stimulation of 0.9 Hz applied for 15 min. Results: Interictal spikes were reduced after electric cortical stimulation of the epileptic area at a frequency of 50 Hz as well as 0.9 Hz, with concomitant decrease in the electrographic fast activities at 50-Hz stimulation. Conclusions: These data suggest that electric cortical stimulation at both high and low frequency has a suppressive effect on epileptic activities in human cortex, possibly through distinct mechanisms. |
| Keywords: | Epilepsy Electric stimulation |
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