| 二氢卟吩e_6的合成及其光敏化力和肿瘤光生物活性 |
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| 引用本文： | 姚建忠,沈卫镝,陈文晖,刘建飞,周有骏. 二氢卟吩e_6的合成及其光敏化力和肿瘤光生物活性[J]. 中国医药工业杂志, 2000, 0(5) |
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| 作者姓名： | 姚建忠 沈卫镝 陈文晖 刘建飞 周有骏 |
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| 作者单位： | 第二军医大学!上海200433 |
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| 基金项目： | 国家自然科学基金资助项目 !( No.3 95 2 2 0 0 3 ) |
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| 摘 要： | 由蚕沙叶绿素粗品 ,经酸碱降解反应制得二氢卟吩 e6 (1) ;并测定了 1在 D2 O中对 NADPH光氧化作用的敏化效应和对小鼠 S1 80 肉瘤的光动力损伤作用。初步试验结果表明 :1在非细胞体系内的光敏化力和对小鼠 S1 80 肉瘤的光动力疗效均优于参比药物血卟啉衍生物 (HPD)
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| 关 键 词： | 蚕沙 叶绿素 二氢卟吩e6 合成 光动力治疗 肿瘤 光敏剂 |
Synthesis and Photosensitizing Abilities and Tumor photobiological Activities of Chlorin e 6 |
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| YAO Jian Zhong ,SHEN Wei Di,CHEN Wen Hui,LIU Jian Fei,ZHOU You Jun. Synthesis and Photosensitizing Abilities and Tumor photobiological Activities of Chlorin e 6[J]. , 2000, 0(5) |
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| Authors: | YAO Jian Zhong SHEN Wei Di CHEN Wen Hui LIU Jian Fei ZHOU You Jun |
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| Affiliation: | YAO Jian Zhong *,SHEN Wei Di,CHEN Wen Hui,LIU Jian Fei,ZHOU You Jun |
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| Abstract: | Chlorin e 6(1) is synthesized via acidic and alkaline degradation reactoins using silkworm excrement crude chlorophyll extract as starting material. Preliminary sensitizing effects of 1 on photooxidation of NADPH in D 2O and photodynamic effects for transplanted sarcoma S 180 in mice have been shown to be stronger than those of HPD. It is suggested that 1 could developed as a new photosensitizer for PDT of cancer.; |
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| Keywords: | silkworm excrement chlorophyll chlorin e 6 synthesis photodynamic therapy tumor photosensitizer |
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