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Levels of Soluble CD40 Ligand and P-Selectin in Nonalcoholic Fatty Liver Disease |
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| Authors: | Cemal Nuri Ercin Teoman Dogru Serkan Tapan Y?ld?r?m Karslioglu Cem Haymana Selim Kilic Alper Sonmez Zeki Yesilova Ahmet Uygun Mustafa Gulsen Sait Bagci M Kemal Erbil |
| Institution: | 1. Department of Gastroenterology, Gulhane School of Medicine, Etlik, Ankara, Turkey 2. Department of Biochemistry, Gulhane School of Medicine, Etlik, Ankara, Turkey 3. Department of Pathology, Gulhane School of Medicine, Etlik, Ankara, Turkey 4. Department of Internal Medicine, Gulhane School of Medicine, Etlik, Ankara, Turkey 5. Department of Epidemiology, Gulhane School of Medicine, Etlik, Ankara, Turkey 6. Department of Endocrinology, Gulhane School of Medicine, Etlik, Ankara, Turkey |
| Abstract: | Nonalcoholic fatty liver disease (NAFLD) is linked to an increased risk of cardiovascular disease. We aimed to research whether the levels of soluble P-selectin (sP-selectin) and soluble CD40 ligand (sCD40L), markers of endothelial function, are altered in subjects with NAFLD having no confounding factors for atherosclerosis. sCD40L, sP-selectin, and high-sensitivity C-reactive protein (hsCRP) levels, and homeostasis model assessment of insulin resistance (HOMA-IR) indexes were measured in 50 NAFLD subjects and 30 healthy controls. sCD40L, sP-selectin, and hsCRP levels were not significantly different between two groups (P = 0.48, 0.51, and 0.34, respectively). Body mass index, waist circumference, and insulin levels and HOMA indexes were significantly higher in subjects with NAFLD (all P < 0.001). The present data show that sCD40L and sP-selectin may not contribute to the accelerated atherogenesis associated with this clinically relevant condition. |
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