OCT比较高眼压和原发性开角型青光眼的视网膜神经纤维层厚度

目的采用光学相干断层扫描技术（OCT）测得正常人、高眼压者和原发性开角型青光眼患者的视网膜神经纤维层（RNFL）的厚度并进行比较。方法选取门诊就诊的患者和正常志愿者，根据眼压、视野和视乳头形态分为正常组76名（152眼），高眼压组70例（109眼），原发性开角型青光眼组67例（112眼），采用OCTCIRRUSZeiss分别测得3组的平均RNFL和4个象限的RNFL。结果正常组平均RNFL为（107．61±8．03）μm，高眼压组平均RNFL为（105．26±9．22）μm，原发性开角型青光眼组平均RFNL为（91．00±10．55）μm。正常人平均、上方和下方RNFL与原发性开角型青光眼患者比较差异有统计学意义（P〈0．01）；高眼压组与原发性开角型青光眼组之间平均RNFL比较差异有统计学意义（P〈0．01）；正常组和高眼压组之间平均RNFL比较差异无统计学意义（P〉0．05）。结论通过对RNFL厚度的分析，为高眼压和原发性开角型青光眼的鉴别诊断提供帮助。

Retinal nerve fiber layer thickness evaluation in ocular hypertensive eyes and primary open-angle glaucoma patients using optical coherence tomography

Objective To measure and compare retinal nerve fiber layer （RNFL） thickness by optical coherence tomography （OCT） in normal eyes, ocular hypertensive eyes, and primary open-angle glaucoma patients. Methods The RNFL thickness was measured in 3 groups： normal group （76 cases, 152 eyes）, ocular hypertensive group （70 cases, 109 eyes）, and primary open-angle glaucoma group （67 cases, 112 eyes）. RNFL measurements were taken with OCT CIRRUS Zeiss. Results The average values of RNFL thickness were （ 107.61± 8.03）μm, （ 105.26 ± 9.22）μm, and （91. 00±10.55）μm in normal eyes, ocular hypertensive eyes, and glaucomatous eyes, respectively. Compared normal eyes, RNFL average thickness, superior thickness, and inferior thickness showed significant differences in glaucomatous eyes （P 〈 0.01）. The RNFL average thickness was significantly different between ocular hypertensive eyes and glaucomatous eyes （P〈0. 01）, whereas there was no significant difference between normal and ocular hypertensive eyes （P 〉 0.05）. Conclusion The RNFL thickness measurement is a kind of very useful and objective method to differentiate ocular hypertensive and primary open-angle glaucoma.