| 幽门螺杆菌感染使胃上皮8-羟-2-脱氧鸟苷表达水平增加 |
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| 引用本文： | 王建,潘月龙. 幽门螺杆菌感染使胃上皮8-羟-2-脱氧鸟苷表达水平增加[J]. 浙江临床医学, 2006, 8(12): 1250-1251 |
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| 作者姓名： | 王建 潘月龙 |
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| 作者单位： | 310006,杭州市第一人民医院 |
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| 摘 要： | 目的通过检测胃上皮组织DNA氧化损伤标记物8-羟-2-脱氧鸟苷(oh8dG)表达水平,探讨Hp的致癌性。方法对Hp阳性患者予以PPI三联治疗,以ELISA法分别检测Hp根治前后及Hp阴性胃上皮组织oh8dG含量。结果Hp阳性组胃上皮oh8dG为(2.017±1.134)ng/mg蛋白,明显高于Hp阴性组的(1.289±0.942)ng/mg蛋白(P<0.01),Hp感染患者在抗Hp根治治疗后胃上皮oh8dG较治疗前显著下降(P<0.05)。结论Hp感染增加了胃粘膜组织oh8dG水平并与胃癌发生有关,抗Hp治疗有助于改善胃上皮DNA氧化损伤的程度。
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| 关 键 词： | 8-羟-2'-脱氧鸟苷 幽门螺杆菌 DNA氧化损伤 |
Relationship of Hp infection and expression of oh8dG in gastric mucosa tissues and clinical significance |
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| Wang Jian,et al. Relationship of Hp infection and expression of oh8dG in gastric mucosa tissues and clinical significance[J]. Zhejiang Clinical Medical Journal, 2006, 8(12): 1250-1251 |
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| Authors: | Wang Jian et al |
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| Abstract: | Purpose To detect the expression of oh8dG in gastric mucosa tissues to discuss the carcinogenicity of Hp. Methods In Hp positive patients,they were treated with PPI trigeminy therapy.Oh8dG was detected in Hp positive tissues and Hp negative tissues respectively. Results There was significant increase of oh8dG in Hp infection group compared with the group without Hp infection (P<0.01) and the level of oh8dG decreased significantly after successful eradication of Hp infection(P<0.05). Conclusion Hp infection which increases oh8dG level in gastric mucosa plays an important role in the process of gastric carcinogenesis and antibacterial therapy can improve DNA oxidative damage of gastric mucosa. |
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| Keywords: | 8-hydroxy-2'-deoxyguanosine helicobacter pylori (Hp) DNA oxidative damage |
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