颊黏膜鳞状细胞癌治疗的Meta分析

目的：通过Meta分析,对颊黏膜鳞状细胞癌（颊癌）在单纯局部扩大切除和附加颈部处理、单纯手术和术后辅助放疗情况下的治疗结果分别进行系统评价,从而对这些不同治疗方法的效果作出比较。方法：以“颊黏膜”、“鳞状细胞癌”、“治疗”、“手术”、“颈淋巴清扫术”、“放疗”、“化疗”、“综合治疗”和“预后”为关键词,检索PubMed、Cochrane图书馆临床对照试验注册资料库、中国知网（CNKI）和维普电子期刊网,按纳入和排除标准筛选文献,从入选文献中提取相应数据进行Meta分析。结果：检出文献118篇,入选11篇。用RevMan4.2.10软件分别计算单纯局部扩大切除和附加颈部处理、单纯手术和术后辅助放疗情况下复发率的相对危险度、生存率的优势比以及相关统计学检验数值。结论：早中期颊癌患者,建议同期行颈淋巴清扫术;中晚期颊癌患者,应常规行同期颈淋巴清扫术及术后放疗;pN＋以及切缘阳性患者,应常规行同期颈淋巴清扫术及术后放疗。

A meta analysis on the treatment of buccal squamous cell carcinoma

PURPOSE： To carry out a systematic review on the treatment outcome of buccal squamous cell carcinoma （BSCC） treated with or without neck treatment and with or without radiotherapy after surgery using Meta analysis. METHODS： The following words were used for electronic searching, bueeal mucosa/squamous cell carcinoma/treatment/ therapy/ radiotherapy/ chemotherapy/ combined therapy/ neck dissection/ prognosis within the databases of PubMed, CCTR, CNKI, VIP Information. RESULTS： ll of 118 papers searched out were selected based on the entrance criteria. Relative risk （ RR ） of recurrence rate and odds ratio （ OR ） of survival rate under the condition with/without neck treatment or radiotherapy after surgery was analyzed using the software RevMan4.2.10. CONCLUSIONS： It is recommended that simultaneous neck dissection should be performed for BSCC patients with early stage. Neck dissection and postoperative radiotherapy should be routinely performed for BSCC patients with advanced stage or pathologic positive nodes or positive margin.