| 生物活性颈椎椎间融合器的制作与基本性能研究 |
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| 引用本文： | 吴广森,靳安民,田京,童斌辉,袁岱军,闽少雄,于博.生物活性颈椎椎间融合器的制作与基本性能研究[J].中国组织工程研究与临床康复,2003,7(20):2772-2773. |
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| 作者姓名： | 吴广森 靳安民 田京 童斌辉 袁岱军 闽少雄 于博 |
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| 作者单位： | 解放军第一军医大学珠江医院骨科,广东省广州市,510282 |
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| 基金项目： | 广东省自然科学基金重点项目(2001A302020205)~~ |
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| 摘 要： | 目的采用自行合成的羟基磷灰石(HAp)/左旋聚乳酸(PLLA)复合材料研制颈椎椎间融合器并对其基本理化性能进行检测,探索制备新型的颈椎椎融合器。方法采用化学共沉淀法和开环聚合法制备HAp和PLLA,按35/65质量比共混,经热压模铸加工成颈椎椎间融合器,检测样件的基本理化特征。结果HAp/PLLA复合材料的密度为1.64g/cm3,热压后黏均相对分子量118.309ku,样件平均极限压缩强度为128MPa,E模量5.47GPa。结论HAp/PLLA复合材料是一种化学性能稳定、机械性能良好的生物活性材料,用其制作的椎间融合器能够达到颈椎椎间支撑融合的基本要求。
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| 关 键 词： | 羟基磷灰石类 乳酸盐类 生物相容性材料 颈椎 脊柱融合术 |
| 文章编号： | 1671-5926(2003)20-2772-02 |
| 修稿时间： | 2003年3月13日 |
Fabrications and characteristic studies of biomaterial fusion cage of cervical vertebra |
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| Guang-Sen Wu,An-Min Jin,Jing Tian,Bin-Hui Tong,Dai-Jun Yuan,Shao-Xiong Min,Bo Yu.Fabrications and characteristic studies of biomaterial fusion cage of cervical vertebra[J].Journal of Clinical Rehabilitative Tissue Engineering Research,2003,7(20):2772-2773. |
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| Authors: | Guang-Sen Wu An-Min Jin Jing Tian Bin-Hui Tong Dai-Jun Yuan Shao-Xiong Min Bo Yu |
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| Institution: | Guang-Sen Wu,An-Min Jin,Jing Tian,Bin-Hui Tong,Dai-Jun Yuan,Shao-Xiong Min,Bo Yu,Department of Orthopedics,Zhujia n g Hospital,First Military Medical University,Guangzhou 510282,Guangdong Province,China |
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| Abstract: | Aim To fabri ca te cervical vertebral fusion cage with bio-material composed of hydroxyapatit e (HAp)and poly L-lactic acid(PLLA),to evaluate its basic physical and c hem ical characteristics and to investigate the fabrication of the n ew type fusion cage of cervical verte-bral.Methods HAp ultramicroparticles and PLLA we re pr epared by chemical codeposition and open-loo p polymerization respectively,and compounded in the quality ratio of 35/65.After being heated and pressed i n a mould,the composition was machi ned into samples of cervical vertebr al $$$$ Xiao fu sion cage whose physical and chemi cal characteristics were exam-ined.Results The relative molecular weight of the composition was118.309ku,and its de nsity was 1.64g /cm 3 .The limitation compressive strength of the cage was 128MPa,and i ts el astic modular was 5.47GPa.Conclusion HAp /PLLA composition is a biomateria l with the stable chemical characteristics and perfe ct mechanical function,and the fusion cage made from HAp /PLLA composition basically fuses the functions of cervical spine. |
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| Keywords: | hydroxyapatites lactates biocom patible materials cervical vertebrae spinal fusion |
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