Oncolytic virotherapy as a personalized cancer vaccine |
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Authors: | Li Qi-Xiang Liu Guohong Wong-Staal Flossie |
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Institution: | iTherX Pharmaceuticals, Inc., 10790 Roselle Street, San Diego, CA 92121, USA. li@itherx.com |
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Abstract: | Oncolytic virotherapy has demonstrated multimodal antitumor mechanisms in both preclinical and clinical settings for cancer treatment, including antitumor immunity. Compared with conventional immunotherapy, oncolytic viruses have the advantages of simultaneous cytoreduction and conferring personalized anticancer immunity, but without the need of personalized manufacture. Additionally, oncolytic viruses can be further engineered to delete immunosuppressive viral components and to insert transgenes that enhance antitumor immunity. Finally, combination with new immunomodulating agents (e.g., cyclophosphamide) or cell therapy approaches will likely further augment specific antitumor immunity of virotherapy. Virotherapy could become a new paradigm for potent, safe and practical therapeutic vaccines for cancer. |
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Keywords: | cancer immunotherapy oncolytic virus personalized medicine combination therapy cyclophosphamide antiviral innate immunity adaptive anticancer immunity |
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