FHIT蛋白和P63蛋白在宫颈癌及CIN中的表达及临床意义

目的:探讨子宫颈癌及宫颈上皮内瘤变组织(CIN)中脆性组氨酸三联体基因(FHIT)蛋白和抑癌基因P63蛋白的表达及其与临床病理因素的关系,并分析其相关性。方法:应用免疫组织化学SP法检测宫颈病变组织及CIN中FHIT蛋白和P63蛋白的表达。采用SPSS统计软件分析数据。结果:慢性宫颈炎、CIN、宫颈癌中FHIT低表达与P63高表达(P<0.05)。FHIT和P63蛋白在宫颈鳞癌的表达与患者淋巴结是否转移有关。P63蛋白在宫颈鳞癌的表达与组织分化和临床分期有关。FHIT低表达与P63高表达在宫颈鳞癌及CIN中呈正相关性。结论:FHIT可作为临床监测CIN转归的分子生物学指标,也可以是宫颈鳞癌患者预后判断的参考依据。P63可以成为一个低分化鳞癌的标记因子。FHIT蛋白在CIN中与宫颈鳞癌中的低表达和P63蛋白在CIN中与宫颈鳞癌中的高表达均呈正相关性,因此两个基因在宫颈鳞癌的发生和进展过程中起了很重要的作用。

Clinical significance of expression of FHIT and P63 in cervical carcinoma and CIN

Objective: In order to improve the total effective rate and the total healing rate,we had an experiment which test the result of using burying verrucous tissue combined levamisole during treating patients with refractory verruca plana uncured by using Chinese herbs(20 dose).Methods: Being agreed by the patients,62 patients were devided into the testing group and the contrast group.For the contrast group,the patients just received levamisole at a daily dose of 150mg,3 times,taking medicine 3 days and stop for 10 days,following drugs for up to 3 months.For the testing group,based on receiving the same method of the contrast group,burying verrucous tissue was also used in patients.Results: The total effective rate and the total healing rate in the testing group were both higher than that in the contrast group.Conclusion : The curative effect to refractory verruca plana patients is notable by burying verracous tissue combined withlevamisole.