| 晚期原发性肝癌患者血清PCR－HBV DNA的意义 |
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| 引用本文： | 余宙耀,刘俊彬. 晚期原发性肝癌患者血清PCR－HBV DNA的意义[J]. 医学争鸣, 1994, 0(5) |
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| 作者姓名： | 余宙耀 刘俊彬 |
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| 作者单位： | 西京医院传染病科，空军广州医院传染病科 |
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| 摘 要： | 目的：为进一步研究ＨＢＶ感染与原发性肝细胞癌的关系．方法：ＥＬＩＳＡ法检测血清中ＨＢｓＡｇ，ＨＢｅＡｇ，抗－ＨＢｅ，抗－ＨＢｃ和抗－ＨＢｓ；ＰＣＲ检测血清ＨＢＶＤＮＡ．结果：３７例晚期原发性肝癌患者血清ＨＢ－ｓＡｇ，ＨＢｅＡｇ，抗－ＨＢｅ和抗－ＨＢｃ阳性者分别为１７例（４５．９５％），４例（１０．８１％），１６例（４３．２４％）和９例（２４．３２％），而抗－ＨＢｓ全部阴性．聚合酶链式反应检测ＨＢＶＤＮＡ，１８例（４８．６９％）阳性，非常显著地高于ＨＢｅＡｇ检出率（Ｐ＜０．０１）．抗－ＨＢｅ阳性中有７例ＰＣＲ－ＨＢＶＤＮＡ阳性．ＨＢＶ总感染率８９．１９％．结论：提示原发性肝癌发生与ＨＢＶ感染有关．
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| 关 键 词： | 肝细胞癌，乙型肝炎病毒，乙型肝炎，基因，聚合酶链反应 |
Significance of serum PCR-HBVDNAinpatients with advanced pri-mary hepatocellular carcinoma |
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| YU Zhou- Yao and LIU Jun-Bin. Significance of serum PCR-HBVDNAinpatients with advanced pri-mary hepatocellular carcinoma[J]. Negative, 1994, 0(5) |
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| Authors: | YU Zhou- Yao and LIU Jun-Bin |
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| Affiliation: | YU Zhou- Yao and LIU Jun-Bin Department of Infectious Diseases,Xijing Hospital |
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| Abstract: | Objective: To study the relationship between HBV infection and primary hepatocellular carcinoma (PHC).Methods: Using the ELIS for serum HBsAg ,HBeAg ,anti-HBe,anti-HBc and anti- HBs; serum HBV DNAwasdetectedby polymerase chain reaction(PCR- HBVDNA).Results :In37 cases of advanced PHC with negative anti-HBs, serum HBsAg, HBeAg, anti-HBe and anti-HBc of which positive results were 17 cases (45. 95%), 4 cases (10. 81%), 16 cases(43. 24%)and 9 cases (24. 23%)respectively. The posi-tive result of PCR-HBV DNA was 1 8 cases (48. 65%)which was significantly higher than that of HBeAg(P<0.01).In positive anti- HBe cases 7 showed positive PCR-HBV DNA. HBV infection rate was 89.19% (33/37 cases). Conclusions: The results suggested that HBV infection is closely associated with PHC. |
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| Keywords: | hepotoma hepatitis B virus hepatitis B genetics polymerase chain reaction |
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