| 参附注射液对病毒性心肌炎小鼠心肌能量代谢的保护作用 |
| |
| 引用本文： | 刘琼,周发春,陈建斌.参附注射液对病毒性心肌炎小鼠心肌能量代谢的保护作用[J].重庆医学,2009,38(20). |
| |
| 作者姓名： | 刘琼 周发春 陈建斌 |
| |
| 作者单位： | 1. 重庆医科大学附属第一医院急诊科、中心ICU,400016
2. 重庆医科大学附属第一医院心内科,400016 |
| |
| 基金项目： | 重庆市卫生局基金资助项目 |
| |
| 摘 要： | 目的 探讨参附注射液对病毒性心肌炎(VMC)小鼠心肌能量代谢的保护作用.方法 将雄性Balb/c小鼠随机分为柯萨奇B3病毒(CVB3)感染组、CVB3感染加参附注射液治疗组和对照组.分别采用电镜和形态计量学方法观察心肌线粒体形态、数量和膜磷脂定位;酶细胞化学法分析线粒体细胞色素C氧化酶(CCO)和琥珀酸脱氢酶(SDH)活性.结果 感染组小鼠心肌线粒体大量破坏,膜磷脂严重缺失、定位改变;CCO和SDH活性降低.各时间点治疗组上述各项指标均较感染组显著改善.结论 VMC心肌线粒体结构严重破坏、功能明显下降,参附注射液能有效保护VMC心肌线粒体结构和功能,改善心肌能量代谢.
|
| 关 键 词： | 病毒性心肌炎 线粒体 能量代谢 参附注射液 |
Protective effect of Shenfu injection on myocardial energy metabolism in mice with viral myocarditis* |
| |
| LIU Qiong,ZHOU Fa-chun,CHEN Jian-Bin.Protective effect of Shenfu injection on myocardial energy metabolism in mice with viral myocarditis*[J].Chongqing Medical Journal,2009,38(20). |
| |
| Authors: | LIU Qiong ZHOU Fa-chun CHEN Jian-Bin |
| |
| Institution: | LIU Qiong1,ZHOU Fa-chun1,CHEN Jian-Bin2(1.Department of Emergency , Central Intensive Care Unit,2.Department of Cordis,the First Affiliated Hospital,Chongqing Medical University,Chongqing 400016,China) |
| |
| Abstract: | Objective To investigate the changes of myocardial energy production in mice with viral myocarditis,and to observe the intervention effects of Shenfu injection.Methods The male Balb/c mice were randomly divided into three groups: infected coxsackie B3 virus(CVB3) group(infection group),infected CVB3 and treated with Shenfu injection group(treatment group) and control group.The morphology and membrane phospholipid of myocardial mitochondria were studied by using transmission electronmicroscope morphometry me... |
| |
| Keywords: | viral myocarditis mitochondria energy metabolism Shenfu injection |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
