Synthesis of 2,6-diaryl-substituted pyridines and their antitumor activities |
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Authors: | Son Jong-Keun Zhao Long-Xuan Basnet Arjun Thapa Pritam Karki Radha Na Younghwa Jahng Yurngdong Jeong Tae Cheon Jeong Byeong-Seon Lee Chong-Soon Lee Eung-Seok |
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Affiliation: | College of Pharmacy, Yeungnam University, Kyongsan 712-749, South Korea. |
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Abstract: | For the development of novel antitumor agents, we designed and synthesized 2,6-diaryl-substituted pyridine derivatives bearing three aryl groups, which are the bioisosteres of terpyridine, and evaluated their biological activities. Most of the 18 prepared compounds showed moderate cytotoxicity against several human cancer cell lines. From the structure-activity relationships we may conclude that the number of aryl groups employed would be critical for their biological activities. |
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