| 过量碘对仔鼠海马组织烯醇化酶活性的影响 |
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| 引用本文： | Sun S,Yin G,Feng Z,Zhao J,Zhu H. 过量碘对仔鼠海马组织烯醇化酶活性的影响[J]. 中华预防医学杂志, 2000, 34(1): 39-40 |
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| 作者姓名： | Sun S Yin G Feng Z Zhao J Zhu H |
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| 作者单位： | 孙素菊（石家庄市 河北医科大学生物化学教研室 050017） |
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| 摘 要： | 目的 观察长期摄入过量碘对子代小鼠脑内海马组织烯醇化酶的影响。方法 用高磺水复制出高碘甲状腺肿动物模型,采用酶联免疫法测定甲状腺肿小鼠的子一代和子二代７、１４、２１、３０日龄仔鼠海马组织神经元特异性烯醇化酶（ＮＳＥ）的活性。结果 同碘组子一代、子二代仔鼠从出生至３０日龄ＮＳＥ活性均较适碘对照组降低,且子二代高组１４日仔鼠海马组织ＮＳＥ活性明显低于子一代。结论高碘可使仔鼠脑内ＮＳＥ活性降低,说明高碘
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| 关 键 词： | 碘中毒 仔鼠 海马 烯醇化酶 活性 |
| 修稿时间： | 1999-01-04 |
Effects of excessive iodine on activity of enolase in hippocampus of developing mice |
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| Sun S,Yin G,Feng Z,Zhao J,Zhu H. Effects of excessive iodine on activity of enolase in hippocampus of developing mice[J]. Chinese Journal of Preventive Medicine, 2000, 34(1): 39-40 |
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| Authors: | Sun S Yin G Feng Z Zhao J Zhu H |
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| Affiliation: | Department of Biochemistry, Hebei Medical University, Shijiazhuang, 050017, China. |
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| Abstract: | Objective Tostudytheeffectsofexcessiveintakeofiodineforalongtermonactivityof enolaseinhippocampaltissuesofyoungmice .Methods Ahyperiodinegoiteranimalmodelwasreplicatedwith drinkingwaterwithhighlevelofiodine.Activityofneuronspecificenolase (NSE)inhippocampaltissueswas determinedwithenzyme linkedimmunosorbentassay (ELISA)foryoungoffspringofthefirstandthesecond generationsofmicewithhyperiodinegoiteronthe 7th ,14thand 2 1stdayofage ,respectively .Results Activity ofenolaseinyoungoffspringofthefirstandsecondgenerationofmicewithhyperiodinegoiterwasalllowerthan thatincontrolsfromthedayoftheirbirthtothe 3 0thdayafterbirth ,andthatathippocampaltissuesinyoungmice ofthesecondgenerationwassignificantlylowerthanthatofthefirstgenerationonthe 14thdayofage .Conclusion HyperiodinecandecreaseactivityofNSEinthebrainofmice .ItsuggeststhathyperiodinecanaffectNSE ,and thusinterfereenergysupplyinthebrain ,resultingindisturbanceofneurondevelopmentandbrainfunction . |
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| Keywords: | Iodine Hippocampus Phosphopyruvatehydratase |
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