131例药品不良反应回顾性分析

目的：探讨医院药品不良反应（ADR）的发生情况及引发ADR的相关因素。方法：将医院2006年收集到的131例ADR进行分类汇总，并加以统计分析。结果：131例ADR中，化学药品引发121例，中成药引发10例。在121例化学药品所致ADR中，静脉给药引发者最多，占总例数的49．62％；抗微生物药引起的ADR居首位；皮肤及附件损害是ADR的最主要表现，占总例数的52．89％（64例），而较严重的ADR有10例。结论：ADR的发生与给药途径、药品种类等多种因素相关，应加强对ADR的监测及相关知识的宣传，以减少和避免ADR的发生。

Retrospective Analysis of 266 Adverse Drug Reaction Cases

Objective： To observe the occurrence of ADRs in a hospital and analyze its correlative iactors. Method： 131 ADR cases collected in a hospital in 2006 were categorized statistically analyzed. Result： 121 of the 131 ADR cases were induced by chemical drugs, and the other 10 cases, induced by the traditional Chinese drugs. In the 121 ADR cases induced by chemical drug, the most were induced by intravenous injection, which occupied 49.62%. Antimicrobial drugs were the first category of drugs to cause ADRs, totaling 77 cases from 42 drugs. ADR most commonly manifested themselves in the injury of skin and appendents, which accounted for 52.89% （64 cases）. There were 10 comparatively serious ADR cases. Conclusion： The occurrence of ADRs was related to many factors, such as administration route and drug varieties. ADRs monitoring and publicizing of ADRs knowledge should be strengthened so as to lessen and avoid the occurrence of ADRs.