| 喉癌患者性激素及分子细胞遗传学研究 |
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| 引用本文： | 王云英,高岭,魏红军,赵书佑. 喉癌患者性激素及分子细胞遗传学研究[J]. 中国优生与遗传杂志, 2002, 10(4): 36-38 |
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| 作者姓名： | 王云英 高岭 魏红军 赵书佑 |
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| 作者单位： | 青岛大学医学院附属青岛市市立医院遗传室,266011 |
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| 摘 要： | 目的 研究喉癌患者性激素及其性染色体改变。方法 采用放免法和荧光原位杂交 (FISH)技术。结果 2 5例喉癌患者中 13例血清睾酮升高 ,9例雄激素升高 ,雌激素正常。 15例喉癌组织中 73 3%的病例呈现X染色体着丝粒拷贝增加 ,9例 (6 0 % )出现Y染色体丢失。结论 性激素及性染色体的改变在喉癌的发生发展中可能起重要作用。
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| 关 键 词： | 喉癌 性激素 染色体 荧光原位杂交 |
| 修稿时间： | 2001-06-21 |
Sex hormone and molecular cytogenetics study on the case with laryngocarcinoma. |
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| Wang Yunying ,Gao Ling,Wei Hongjun,Zhao Shuyou.. Sex hormone and molecular cytogenetics study on the case with laryngocarcinoma.[J]. Chinese Journal of Birth Health & Heredity, 2002, 10(4): 36-38 |
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| Authors: | Wang Yunying Gao Ling Wei Hongjun Zhao Shuyou. |
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| Affiliation: | Wang Yunying 1,Gao Ling,Wei Hongjun,Zhao Shuyou. |
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| Abstract: | Objective: To study sex hormone change and chromosome aberration in the case of laryngocarcinoma. Methods: Radio immuno assay and fluorescence in situ hybridization technique were used. Results: In 25 patients there are 13 cases serum testosterone heightened and serum androgen increased in 9 cases. While serum estrogen was normal. Overpresentation of DXZ1 was detected in 73.3% cases and loss of chromosome Y was found in 60%(9/15) cases. Conclusion: Sex hormone and chromosome aberration may play an important role in the pathogenesis and growth of laryngocarcinoma. |
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| Keywords: | Laryngocarcinoma Sex hormone Chromosome Fluorescence in situ hybridization |
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