人参白虎汤对2型糖尿病大鼠血糖、血脂及其胰岛素耐量的影响

目的:探讨人参白虎汤治疗2型糖尿病的作用及其机制.方法:高脂饲料喂养大鼠4周,腹腔注射链脲佐菌素(STZ)制备2型糖尿病大鼠模型.糖尿病大鼠随机分为模型组、人参白虎汤高(15 g·kg-1)、中(7.5 g·kg-1)、低剂量组(3.7 g·kg-1)和二甲双胍组(0.2 g·kg-1).人参白虎汤高、中、低剂量组分别ig不同剂量的人参白虎汤,二甲双胍组ig二甲双胍,模型组与对照组ig等量自来水.给药4周后取血,测定血糖(Glu)、血脂、糖耐量、糖化血红蛋白(HbA1c)、胰岛素(Ins)和胰岛素耐量的变化.结果:人参白虎汤能明显降低糖尿病大鼠的Glu(P＜0.05或P＜0.01)、胆固酵(TC)(P＜0.05或P＜0.01)、甘油三酯(TG)(P＜0.05或P＜0.01)含量,升高高密度脂蛋白(胆固醇HDL-C)含量(P＜0.05),改善糖耐量(P ＜0.05或P＜0.01),增强糖尿病大鼠Ins敏感性(P＜0.05或P＜0.01),但对Ins含量影响不明显.结论:人参白虎汤在降血糖、降血脂、改善糖耐量、增强Ins敏感性方面作用显著,其降糖作用可能与增强大鼠对Ins敏感性有关.

Effects of Renshen Baihu Decoction on Blood Glucose, Blood Lipid and Insulin Tolerance in Rats with Non-insulin-dependent Diabetes Mellitus

Objective: To study the effect and pharmacological mechanism of Renshen Baihu decoction in non-insulin-dependent diabetes mellitus (NIDDM) rats. Method: The rats were bred with high lipid special food for 4 weeks, then intraperitoneal injected streptozotocin (STZ) to establish the NIDDM animal model. After that, the rats were administrated with Renshen Baihu decoction (15, 7.5, 3.7 g·kg^-1, respectively) or metformin, respectively. Model group and control group animal were administrated with tap water. 4 weeks later, observed the contents of blood glucose, blood lipid and insulin, glucose and insulin tolerance to analyze the influence of Renshen Baihu decoction on NIDDM animal model. Result: Renshen Baihu decoction obviously decreased the amount of blood glucose(P<0.05 or P<0.01), triglyceride(P<0.05 or P<0.01), and cholesterol(P<0.05 or P<0.01), increased the amount of high-density lipoproteins(P<0.05), improved glucose and insulin tolerance(P<0.05 or P<0.01), reinforced the sensitivity of rat to exogenous insulin(P<0.05 or P<0.01), but showed less effect on the content of insulin. Conclusion: Renshen Baihu decoction had significant effect to decrease blood glucose, triglyceride and cholesterol, improved glucose tolerance, reinforced the sensitivity to exogenous insulin. Its hypoglycemic effect maybe due to it strengthened the sensitivity of insulin of the animal.