| 大黄饮片模拟炮制研究 |
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| 引用本文： | 李丽,张村,肖永庆,王云,陈东东,田国芳.大黄饮片模拟炮制研究[J].中华中医药杂志,2011(8):777-780. |
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| 作者姓名： | 李丽 张村 肖永庆 王云 陈东东 田国芳 |
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| 作者单位： | 中国中医科学院中药研究所中药炮制研究中心; |
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| 基金项目： | 国家自然基金重点项目(No.30730111)~~ |
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| 摘 要： | 目的:通过组分填充模拟炮制方法,探讨大黄饮片炮制前后主要成分的变化规律。方法:以"空白饮片"为载体,填充不同组分进行生大黄、酒大黄、醋大黄、熟大黄和大黄炭饮片的模拟炮制,采用HPLC法分析比较不同组分模拟大黄饮片的主成分变化规律。结果:炮制以后,大黄中的苷类成分主要表现为自身的破坏及向其相应苷元转化,同时其相应的苷元也存在着自身破坏与相应苷类成分向其转化的动态过程。由于部分苷类成分中含有没食子酯基,因此炮制过程中,不仅可转化为相应的苷元,还分解产生没食子酸。另外,鞣质类成分炮制后,一部分被完全破坏,另一部分转化为儿茶素、没食子酸等单体鞣质。这也是大黄熟片和炭片中没食子酸含量显著增加的原因。结论:以空白饮片为载体的组分填充模拟炮制方法与其他模拟炮制方法相比,可以较为真实地反映化学成分在炮制过程中的变化情况,是中药炮制原理研究的一种有效的新方法。
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| 关 键 词： | 大黄 空白饮片 模拟炮制 |
Study on simulation processing method for rhubarb pieces |
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| LI Li,ZHANG Cun,XIAO Yong-qing,WANG Yun,CHEN Dong-dong,TIAN Guo-fang.Study on simulation processing method for rhubarb pieces[J].China Journal of Traditional Chinese Medicine and Pharmacy,2011(8):777-780. |
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| Authors: | LI Li ZHANG Cun XIAO Yong-qing WANG Yun CHEN Dong-dong TIAN Guo-fang |
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| Institution: | LI Li,ZHANG Cun,XIAO Yong-qing,WANG Yun,CHEN Dong-dong,TIAN Guo-fang(Processing Chinese Medicine Research Center,Institute of Chinese Materia Madica,China Academy of Chinese Medical Sciences,Beijing 100700,China) |
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| Abstract: | Objective:To research on the variation laws of main constituents in the pieces of rhubarb by the simulation processing method.Methods:Taken the 'blank pieces' as the carrier and filled with different components from rhubarb,then processed as five kinds of pieces.HPLC chromatography were used to analysis the changes of main components.Results:After processing,the glycosides were destroyed and converted to its corresponding aglycone,while the corresponding aglycones there were also self-destruction and increa... |
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| Keywords: | Rhubarb Blank pieces Simulation processing |
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