| 肉桂油对大鼠内分泌-免疫系统的影响 |
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| 引用本文： | 张倩,张冰,李连珍,冉剑虹,林志健.肉桂油对大鼠内分泌-免疫系统的影响[J].中华中医药杂志,2011(8):723-726. |
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| 作者姓名： | 张倩 张冰 李连珍 冉剑虹 林志健 |
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| 作者单位： | 北京中医药大学中药学院; |
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| 基金项目： | 国家重点基础研究发展计划(973计划)(No.2007CB512605); 国家自然科学基金资助项目(No.81073068)~~ |
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| 摘 要： | 目的:探讨肉桂挥发油对正常大鼠内分泌系统及免疫系统的影响。方法:雄性SD大鼠40只,设为正常对照组、肉桂油大、中、小剂量组(600、400、200mg/kg)4组,持续给药7d后,取胸腺、脾脏,计算脏器指数;腹主静脉取血,分离血清,全自动生化仪检测血清IgM、IgG、C3、C4含量,放免法检测血清T3、T4、TSH、CORT、E2、T等指标含量。结果:与正常对照组比较,给药组动物胸腺指数降低,脾脏指数有降低趋势;血清T3、T4、E2、IgM、IgG降低;CORT、C3、C4明显升高;T呈降低趋势;TSH变化不明显。结论:肉桂油可以使正常大鼠内分泌、免疫系统出现紊乱,能抑制甲状腺轴、性腺轴,兴奋肾上腺轴,对免疫系统有一定的抑制。肉桂油给予正常大鼠可以在一定程度上模拟阴虚病理模型。
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| 关 键 词： | 肉桂油 内分泌系统 免疫系统 |
Effect of Oleum Cinnamomi on endocrine and immune system in normal rats |
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| ZHANG Qian,ZHANG Bing,LI Lian-zhen,RAN Jian-hong,LIN Zhi-jian.Effect of Oleum Cinnamomi on endocrine and immune system in normal rats[J].China Journal of Traditional Chinese Medicine and Pharmacy,2011(8):723-726. |
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| Authors: | ZHANG Qian ZHANG Bing LI Lian-zhen RAN Jian-hong LIN Zhi-jian |
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| Institution: | ZHANG Qian,ZHANG Bing,LI Lian-zhen,RAN Jian-hong,LIN Zhi-jian(Chinese Meteria Medica School,Beijing University of Chinese Medicine,Beijing 100029,China) |
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| Abstract: | Objective:To observe the effect of Oleum Cinnamomi on endocrine and immune system in normal rats.Methods:40 Male Sprague Dawley(SD) rats were divided into four groups randomly:normal control group and Oleum Cinnamomi treated groups at dose of 600,400,200mg/kg.Oleum Cinnamomi was given by intragastric administration daily for a week period.Thymus and spleen were removed and weighted,and then calculated the index.Blood samples were collected from abdominal vein.IgM,IgG,C3,C4 in serum were measured by automati... |
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| Keywords: | Oleum Cinnamomi Endocrine system Immune system |
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