高良姜油对胃溃疡小鼠模型血清NO、SOD及MDA的影响

目的:研究高良姜油对胃溃疡小鼠模型血清一氧化氮(NO)、超氧化物歧化酶(SOD)及丙二醛(MDA)的影响。方法:ICR小鼠随机分成8组:正常组、模型组、山莨菪碱片组(0.005g/kg)、奥美拉唑组(0.014g/kg)、良附丸组(2g/kg),高良姜油高、中、低剂量组(8、4、2mL/kg),预防给药6d后,采用利血平致胃溃疡小鼠模型,测定小鼠血清NO含量、SOD活性及MDA含量。结果:与模型组相比,高良姜油的高、中剂量组、良附丸组、奥美拉唑组、山莨菪碱组均能增加利血平致胃溃疡小鼠模型血清NO含量和SOD活性,降低MDA含量(P<0.05,P<0.01)。结论:高良姜油抗胃溃疡作用机制可能与其抗氧化、舒张血管作用有关。

Effect of oils in alpinia officinarum hance on serum NO,SOD,MDA in gastrelcosis mice model

Objective: To explore effects of Oils in alpinia officinarum hance(OAOH)on NO,SOD,MDA of gastrelcosis mice model.Method: ICR mice were randomly divided into 8 groups:control group,modle group,racanisodimine group(0.005g/kg),Omeprazole group(0.014g/kg),liangfu pills group(2g/kg),OAOH high dosage group,OAOH middle dosage group,OAOH low dosage group(8、4、2mL/kg).The gastrelcosis mice model was induced by reserpine,which was then given drugs for 6 days.Nitric oxide(NO) content,superoxide dismutase(SOD) activity and malondialdehyde(MDA) content in mice serum were determined.Result: Compared with the model group: OAOH(H,M),liangfu pills,Omeprazole group,racanisodimine group obviously ncreased the content of NO and active of SOD in serum,decreased the content of MDA in serum(P<0.05,P<0.01).Conclusion: OAOH treats gastrelcosis by eliminating free radical and improving local blood circulation of the ulcer.