| 众生丸体内抗H9N2亚型禽流感病毒的研究 |
| |
| 引用本文： | 李耿,陈纹平,陈建新,申小花,林吉,赖小平. 众生丸体内抗H9N2亚型禽流感病毒的研究[J]. 中华中医药杂志, 2011, 0(8): 816-819 |
| |
| 作者姓名： | 李耿 陈纹平 陈建新 申小花 林吉 赖小平 |
| |
| 作者单位： | 广州中医药大学中药学院中药学教研室;华南农业大学兽医学院农业部动物疫病防控重点开放实验室;广州中医药大学中医药数工程研究院; |
| |
| 基金项目： | 国家自然科学基金重点项目(No.U0732004); 广东省科技计划(No.2006B21101005); 广东省东莞市科技计划(No.200910810231)~~ |
| |
| 摘 要： | 目的:研究众生丸对滴鼻感染H9N2亚型禽流感病毒的小鼠的治疗作用。方法:以利巴韦林及达菲为阳性对照,通过小鼠滴鼻感染H9N2亚型禽流感病毒,分别建立小鼠禽流感病毒性肺炎动物模型和禽流感病毒感染致小鼠死亡的动物模型,观察小鼠肺部病变和死亡情况,评价众生丸对感染H9N2亚型禽流感病毒小鼠的治疗效果。结果:众生丸高中低剂量均可显著降低禽流感病毒性肺炎小鼠的肺指数(P<0.05,P<0.01),能减少感染小鼠的死亡数,延长平均存活时间,但与病毒对照组比较无统计学差异。结论:众生丸对滴鼻感染禽流感病毒H9N2亚型的小鼠有一定的治疗作用。
|
| 关 键 词： | 众生丸 禽流感 H9N2 小鼠 体内 |
Experimental study of anti-influenza virus H9N2 of Zhongsheng Pill in vivo of mice |
| |
| LI Geng,CHEN Wen-ping,CHEN Jian-xin,SHEN Xiao-hua,LIN ji,LAI Xiao-ping. Experimental study of anti-influenza virus H9N2 of Zhongsheng Pill in vivo of mice[J]. China Journal of Traditional Chinese Medicine and Pharmacy, 2011, 0(8): 816-819 |
| |
| Authors: | LI Geng CHEN Wen-ping CHEN Jian-xin SHEN Xiao-hua LIN ji LAI Xiao-ping |
| |
| Affiliation: | LI Geng1,CHEN Wen-ping1,CHEN Jian-xin2,SHEN Xiao-hua1,LIN ji1,LAI Xiao-ping1,3(1Herbal Medicine Research Institute,Herbal Medicine Research College in Guangzhou University of TCM,Guangzhou 510006,China,2College and Animal Academy in South China Agriculture University,Guangzhou 510642,3Mathematical Engineering Academy of Chinese Medicine,Guangzhou University of TCM,Dongguan 523808,China) |
| |
| Abstract: | Objective:To study the Zhongsheng Pill on the intranasal infection of H9N2 subtype avian influenza virus of mice.Methods:Ribavirin as a positive control,mice were intranasally infected by H9N2 subtype avian influenza virus,avian influenza virus in mice were established animal models of pneumonia and avian influenza virus infection in mice caused by the death of animal models to observe the small mouse lung lesions and death to study the Zhongsheng Pill vivo avian influenza virus subtype H9N2 infection in mi... |
| |
| Keywords: | Creatures pill Avian flu H9N2 Mice In vivo |
| 本文献已被 CNKI 等数据库收录！ |
|
