| 新疆天山乌头草的急性毒性试验研究 |
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| 引用本文： | 管小江,李光来,侯新华,苏振磊,马海棠,田春霞,郑秋生,于拔萃.新疆天山乌头草的急性毒性试验研究[J].中华中医药杂志,2011(8):850-852. |
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| 作者姓名： | 管小江 李光来 侯新华 苏振磊 马海棠 田春霞 郑秋生 于拔萃 |
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| 作者单位： | 新疆哈密红星医院急诊科;石河子大学药学院新疆特种植物药资源教育部重点实验室; |
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| 基金项目： | 新疆生产建设兵团科学技术局2009年度兵团科技计划(No.2009GG52)~~ |
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| 摘 要： | 目的:弄清新鲜乌头草对小鼠的急性毒性。方法:野外采集新鲜乌头草,立即粉碎榨汁,得到新鲜乌头草汁,小鼠灌胃给药,测定新鲜乌头草的半致死量LD50,观察小鼠所出现的毒性反应,并测定小鼠血清的生化指标和心脏的氧化还原指标的变化。结果:以新鲜乌头草量计,乌头草对小鼠的LD50是7.550g/kg;乌头草高剂量组小鼠血清中丙氨酸氨基转移酶(ALT)、门冬氨酸转移酶(AST)、总蛋白(TP)、白蛋白(ALB)、尿素(Urea)、尿酸(Uric Acid)、肌酸激酶(CK)、α-羟丁酸脱氢酶(α-HBDH)、乳酸脱氢酶(LDH)、肌酸激酶同工酶(CK-MB)与对照组相比均有显著性升高;与对照组相比,心脏组织中丙二醛(MDA)含量显著升高、总抗氧化能力(T-AOC)显著降低,以及乳酸脱氢酶(LDH)活力显著降低。结论:新鲜乌头草有很大的急性毒性,主要毒性靶器官是心脏组织。
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| 关 键 词： | 乌头草 急性毒性 半数致死量 氧化还原 |
Study on acute toxicity test of Xinjiang Tianshan Mountains' Aconitum carmichaelii herb |
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| GUAN Xiao-jiang,LI Guang-lai,HOU Xin-hua,SU Zhen-lei,MA Hai-tang,TIAN Chun-xia,ZHENG Qiu-sheng,YU Ba-cui.Study on acute toxicity test of Xinjiang Tianshan Mountains' Aconitum carmichaelii herb[J].China Journal of Traditional Chinese Medicine and Pharmacy,2011(8):850-852. |
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| Authors: | GUAN Xiao-jiang LI Guang-lai HOU Xin-hua SU Zhen-lei MA Hai-tang TIAN Chun-xia ZHENG Qiu-sheng YU Ba-cui |
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| Institution: | GUAN Xiao-jiang1,LI Guang-lai1,HOU Xin-hua1,SU Zhen-lei1,MA Hai-tang1,TIAN Chun-xia1,ZHENG Qiu-sheng2,YU Ba-cui2(1Emergency Department of Xinjiang Hami Red Star Hospital,Hami 839000,China,2Key Laboratory of Xinjiang Endemic Phyto-medicine Resources,School of Pharmacy,Shihezi University,Shihezi 832002,China) |
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| Abstract: | Objective:To explore the acute toxicity of fresh Caulis et Folium Aconitum carmichaeli Debx.in mice.Methods:The fresh Caulis et Folium Aconitum carmichaeli Debx.was shivered and pressed.The obtained juice were treated with a single oral dose,The medial lethal dose(LD50) of fresh Caulis et Folium Aconitum carmichaelii was determined in mice;the toxic reaction was observed;the serum samples were collected for biochemical analysis and the cardiac tissues were used to quantitated the redox state.Results:The LD5... |
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| Keywords: | Aconitum carmichaelii herb Acute toxicity Medial lethal dose(LD50) Redox |
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